Description

  • Product name

    Hepatitis C Virus genotype 3a NS5 protein
  • Biological activity

    ab68626 is immunoreactive with sera of HCV-infected individuals.
  • Purity

    > 95 % SDS-PAGE.
    ab68626 was purified by a proprietary chromatographic technique.
  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Additional sequence information

      The E.coli derived recombinant protein fused to a GST tag contains the HCV NS5 Genotype 3 immunodominant regions.
  • Description

    Recombinant Hepatitis C Virus genotype 3a NS5 protein

Specifications

Our Abpromise guarantee covers the use of ab68626 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Immunoreactive with sera of HCV-infected individuals.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Constituents: 9% Urea, 0.395% Tris HCl, 0.0292% EDTA, 50% Glycerol

General Info

  • Alternative names

    • HCV NS5
    • Hepatitis C virus NS5
    • Non structural protein 5A
    • NS5A
    • p56
    see all
  • Relevance

    HCV is classified into the genus Hepacivirus of the family Flaviviridae. Like all the members of the family, HCV is an enveloped, single-stranded, positive-sense RNA virus. Its genome (about 9600 nt) is flanked at both termini by conserved, highly structured non-translated regions (NTRs) and encodes a polyprotein precursor (about 3000 aa), which is proteolytically processed by host and viral proteases to produce the structural (core, E1, E2 and p7) and non-structural (NS2, NS3, NS4A, NS4B, NS5A and NS5B) proteins of the virus. Recently, an additional protein has been identified, whose function remains unknown. NS5A is a ~56 kDa pleiotropic protein with key roles in both viral RNA replication and modulation of the physiology of the host cell. It's exact role is not currently known (2008). NS5B RNA-dependant RNA polymerase is responsible for replication of the hepatitis C viral genome, and is currently a principal target for chemotherapeutic inhibition of HCV replication.

References

ab68626 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer

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Please be advised that these products are for research use only. They should not be consumed in any circumstances. These are not for therapeutic use.

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