• Product name
    Anti-Hepatitis C virus NS5B antibody
  • Description
    Rabbit polyclonal to Hepatitis C virus NS5B
  • Host species
  • Tested applications
    Suitable for: WB, IP, ELISAmore details
  • Species reactivity
    Reacts with: Hepatitis C virus
  • Immunogen

    Recombinant protein NS5B (part of the NAS5AB recombinant antigen) from Hepatitis C virus with C-terminal truncation of 21 amino acid residues.

  • Positive control
    • Hepatitis C Virus NS5B expressed in Huh7 cells



Our Abpromise guarantee covers the use of ab65410 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 65 kDa.
IP Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.


  • Relevance
    HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins, and several non-structural proteins necessary for viral replication, of which NS5B is one. NS5B RNA-dependant RNA polymerase is responsible for replication of the hepatitis C viral genome, and is currently a principal target for chemotherapeutic inhibition of HCV replication. Hepatitis C virus (HCV) can cause chronic hepatitis, cirrhosis and hepatocellular carcinoma. At present there is no vaccine effective against HCV. Host membrane insertion occurs after processing by the NS3 protease.
  • Database links
    • Alternative names
      • HCV NS5B antibody
      • Hepatitis C virus NS5B antibody
      • p68 antibody
      • RNA dependent RNA polymerase antibody
      • RNA directed RNA polymerase antibody
      see all


    This product has been referenced in:
    • Pène V  et al. Dynamic Interaction of Stress Granules, DDX3X, and IKK-a Mediates Multiple Functions in Hepatitis C Virus Infection. J Virol 89:5462-77 (2015). Read more (PubMed: 25740981) »
    • McGivern DR  et al. Protease Inhibitors Block Multiple Functions of the NS3/4A Protease-Helicase during the Hepatitis C Virus Life Cycle. J Virol 89:5362-70 (2015). Read more (PubMed: 25740995) »

    See all 3 Publications for this product

    Customer reviews and Q&As

    Vielen Dank dafür, dass Sie sich die Zeit genommen haben, unseren Fragebogen auszufüllen.

    Es tut mir leid, dass Sie Probleme mit unserem Antikörper hatten.

    Um Ihr Problem zu lösen, möchte ich die folgenden Vorschläge z...

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    Vielen Dank dafür, dass Sie nachhaken.

    Leider haben wir noch keine guten Nachrichten für Sie:

    Wie versprochen haben wir uns in den entsprechenden Laboren erkundigt. Bislang haben wir für unsere anti-HCV NS5B-Antik&oum...

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    Thank you for contacting us. I am sorry for the delay in this response. ab100895 is a Mouse monoclonal antibody to Hepatitis C virus NS5B which has been used previously for ELISA and Western blotting. Unfortunately I have been unable to confirm if this...

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