Overview

  • Product name
    Heptelidic acid (Koningic acid)
  • Description
    Potent, selective, irreversible GAPDH inhibitor. Selective, competitive DNA polymerase inhibitor.
  • Biological description
    Potent, selective, irreversible GAPDH inhibitor. Selective, competitive DNA polymerase inhibitor. Antibiotic agent. Potently inhibits ATP generation in the glycolytic pathway. Inhibits DNA polymerases β, λ and terminal deoxynucleotidyl transferase (TdT) in family X. Inhibits caspase- 3 induction (IC50 = 40 μM). Shows antiapoptotic effects.
  • Purity
    > 95%

Properties

References

This product has been referenced in:
  • Kim JH & Lee CH Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells. J Microbiol Biotechnol 19:787-91 (2009). Read more (PubMed: 19734716) »
  • Gregus Z & Németi B The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase works as an arsenate reductase in human red blood cells and rat liver cytosol. Toxicol Sci 85:859-69 (2005). Read more (PubMed: 15788719) »
  • Endo A  et al. Specific inhibition of glyceraldehyde-3-phosphate dehydrogenase by koningic acid (heptelidic acid). J Antibiot (Tokyo) 38:920-5 (1985). Read more (PubMed: 4030504) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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