Overview

  • Product name

    Anti-HERC1 antibody
  • Description

    Rabbit polyclonal to HERC1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Cow, Pig
  • Immunogen

    Recombinant fragment, corresponding to amino acids 283-397 of Human HERC1.

  • Positive control

    • Human lymph node tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab151071 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Relevance

    Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
  • Cellular localization

    Cell Membrane, Cytoplasmic and Golgi Apparatus
  • Database links

  • Alternative names

    • Guanine nucleotide exchange factor p532 antibody
    • Hect (homologous to the E6 AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1) like domain (RLD) 1 antibody
    • HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 antibody
    • HECT domain and RCC1 like domain containing protein 1 antibody
    • p532 antibody
    • p619 antibody
    • Probable E3 ubiquitin-protein ligase HERC1 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human lymph node tissue labeling HERC1 with ab151071 at 1/50 dilution.

References

ab151071 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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