Overview

  • Product name

    Herkinorin, mu opioid agonist
  • Description

    Non-internalising μ opioid agonist
  • Biological description

    Selective μ opioid receptor agonist derived from the plant product, salvinorin A (ab120084). Does not promote the recruitment of beta-arrestin-2 or lead to receptor internalization.
  • Purity

    > 98%
  • CAS Number

    862073-77-6
  • Chemical structure

    Chemical Structure

Properties

Associated products

Images

  • Primary sensory neurons treated with vehicle (0.1% DMSO) (top panel) and 10 μM of ab120147 for 15 minutes (bottom panel) revealed no significant difference in CFP emission. It does not recruit β-arrestin2 to MOPr in primary sensory neurons.

References

This product has been referenced in:

  • Groer CE  et al. An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization. Mol Pharmacol 71:549-57 (2007). Read more (PubMed: 17090705) »
  • Xu H  et al. A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence. Synapse 61:166-75 (2007). Read more (PubMed: 17152090) »
  • Tidgewell K  et al. Synthesis of salvinorin A analogues as opioid receptor probes. J Nat Prod 69:914-8 (2006). Read more (PubMed: 16792410) »
See all 2 Publications for this product

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