Key features and details
- Non-internalising μ opioid agonist
- CAS Number: 862073-77-6
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameHerkinorin, mu opioid agonist
DescriptionNon-internalising μ opioid agonist
Selective μ opioid receptor agonist derived from the plant product, salvinorin A (ab120084). Does not promote the recruitment of beta-arrestin-2 or lead to receptor internalization.
Chemical name(2S,4aR,6aR,7R,9S,10aS,10bR)-Methyl 9-(benzoyloxy)-2-(furan-3-yl)-dodecahydro-6a,10b-dimethyl-4,10-dioxo-1H-benzo[f]isochromene-7-carboxylate
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
2D chemical structure image of ab120147, Herkinorin, mu opioid agonist
Primary sensory neurons treated with vehicle (0.1% DMSO) (top panel) and 10 μM of ab120147 for 15 minutes (bottom panel) revealed no significant difference in CFP emission. It does not recruit β-arrestin2 to MOPr in primary sensory neurons.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120147 has been referenced in 3 publications.
- Rowan MP et al. Activation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via ß-arrestin-2-mediated cross-talk. PLoS One 9:e93688 (2014). PubMed: 24695785
- Ji F et al. Herkinorin dilates cerebral vessels via kappa opioid receptor and cyclic adenosine monophosphate (cAMP) in a piglet model. Brain Res 1490:95-100 (2013). PubMed: 23103502
- Cui X et al. Ligand interaction, binding site and G protein activation of the mu opioid receptor. Eur J Pharmacol 702:309-15 (2013). PubMed: 23415745