Overview

  • Product name

  • Description

    Rabbit polyclonal to HERPUD1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 9-251 of Human HERPUD1 (Q15011).

  • Positive control

    • 293T and Mouse brain whole cell lysate; Human U251 xenograft tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab155778 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 44 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function

    Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation.
  • Tissue specificity

    Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.
  • Sequence similarities

    Contains 1 ubiquitin-like domain.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • HERP antibody
    • HERP1_HUMAN antibody
    • HERPUD1 antibody
    • Homocysteine inducible endoplasmic reticulum stress inducible ubiquitin like domain member 1 antibody
    • Homocysteine inducible endoplasmic reticulum stress inducible ubiquitin like domain member 1 protein antibody
    • Homocysteine responsive endoplasmic reticulum resident ubiquitin like domain member 1 antibody
    • Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein antibody
    • KIAA0025 antibody
    • Methyl methanesulfonate (MMF) inducible fragment protein 1 antibody
    • Methyl methanesulfonate (MMF)-inducible fragment protein 1 antibody
    • MIF1 antibody
    • MMS inducible antibody
    • SUP antibody
    see all

Images

  • Anti-HERPUD1 antibody (ab155778) at 1/1000 dilution + Mouse brain whole cell lysate at 50 µg

    Predicted band size: 44 kDa



    10% SDS PAGE
  • Anti-HERPUD1 antibody (ab155778) at 1/5000 dilution + 293T whole cell lysate at 30 µg

    Predicted band size: 44 kDa



    7.5% SDS PAGE
  • Immunohistochemical analysis of paraffin-embedded Human U251 xenograft tissue, labeling HERPUD1 with ab155778 at 1/500 dilution.

References

This product has been referenced in:

  • Villar VH  et al. mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation. Nat Commun 8:14124 (2017). Read more (PubMed: 28112156) »
See 1 Publication for this product

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