• Product name

  • Description

    Rabbit polyclonal to HERV-FRD
  • Host species

  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee, Cynomolgus monkey, Gorilla, Orangutan
  • Immunogen

    Recombinant fragment corresponding to Human HERV-FRD aa 16-250.


    Database link: P60508

  • Positive control

    • WB: HeLa, HepG2 and A431 whole cell lysate. IHC-P: Human kidney and adrenal gland tissue.
  • General notes

    Previously labeled as HERV.



Our Abpromise guarantee covers the use of ab230235 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).
IHC-P 1/20 - 1/200.


  • Function

    Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. Can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.
    SU mediates receptor recognition.
    TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane.
  • Tissue specificity

    Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.
  • Sequence similarities

    Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily.
  • Domain

    Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo.
  • Post-translational

    Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.
    The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion.
  • Cellular localization

    Cell membrane and Virion.
  • Information by UniProt
  • Database links

  • Alternative names

    • EFRD1_HUMAN antibody
    • Endogenous retrovirus group FRD member 1 antibody
    • Envelope polyprotein antibody
    • ERVFRD-1 antibody
    • FLJ41944 antibody
    • FLJ90611 antibody
    • GLLL6191 antibody
    • HERV FRD 6p24.1 provirus ancestral Env polyprotein antibody
    • HERV FRD antibody
    • HERV FRD provirus ancestral Env polyprotein antibody
    • HERV-FRD antibody
    • HERVFRD antibody
    • HERVFRD provirus ancestral Env polyprotein antibody
    • MGC87585 antibody
    • SU antibody
    • Syncytin 2 antibody
    • Syncytin B antibody
    • Syncytin-2 antibody
    • TM antibody
    • Transmembrane protein antibody
    • UNQ6191 antibody
    see all


  • All lanes : Anti-HERV-FRD antibody (ab230235) at 1/1000 dilution

    Lane 1 : HeLa (Human epithelial cell line from cervix adenocarcinoma) whole cell lysate
    Lane 2 : HepG2 (Human liver hepatocellular carcinoma cell line) whole cell lysate
    Lane 3 : A431 (Human epidermoid carcinoma cell line) whole cell lysate

    All lanes : Goat polyclonal to rabbit IgG at 1/10000 dilution

    Developed using the ECL technique.

    Predicted band size: 60 kDa
    Observed band size: 60 kDa

  • Paraffin-embedded human kidney tissue stained for HERV-FRD with ab230235 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human adrenal gland tissue stained for HERV-FRD with ab230235 at 1/100 dilution in immunohistochemical analysis.


ab230235 has not yet been referenced specifically in any publications.

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