• Product name
  • Description
    Rabbit polyclonal to HERV-FRD
  • Host species
  • Tested applications
    Suitable for: ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee
  • Immunogen

    A synthetic peptide corresponding to a region within N terminal amino acids 36 - 85 (


    ) of Human HERV-FRD (NP_997465)

  • Positive control
    • HT1080 cell lysate This antibody gave a positive result when used in the following formaldehyde fixed cell lines: HeLa.


  • Form
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituents: PBS, 2% Sucrose
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab90733 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 5 µg/ml.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function
    Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. Can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.
    SU mediates receptor recognition.
    TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane.
  • Tissue specificity
    Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.
  • Sequence similarities
    Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily.
  • Domain
    Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo.
  • Post-translational
    Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.
    The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion.
  • Cellular localization
    Cell membrane and Virion.
  • Information by UniProt
  • Database links
  • Alternative names
    • EFRD1_HUMAN antibody
    • Endogenous retrovirus group FRD member 1 antibody
    • Envelope polyprotein antibody
    • ERVFRD-1 antibody
    • FLJ41944 antibody
    • FLJ90611 antibody
    • GLLL6191 antibody
    • HERV FRD 6p24.1 provirus ancestral Env polyprotein antibody
    • HERV FRD antibody
    • HERV FRD provirus ancestral Env polyprotein antibody
    • HERV-FRD antibody
    • HERVFRD antibody
    • HERVFRD provirus ancestral Env polyprotein antibody
    • MGC87585 antibody
    • SU antibody
    • Syncytin 2 antibody
    • Syncytin B antibody
    • Syncytin-2 antibody
    • TM antibody
    • Transmembrane protein antibody
    • UNQ6191 antibody
    see all


  • ab90733 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab90733 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

  • Anti-HERV-FRD antibody (ab90733) at 1 µg/ml (in 5% skim milk / PBS buffer) + HT1080 cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size: 60 kDa

    Gel concentration: 12%


ab90733 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for your call today. We do not currently sell antibodies against EMV, gag, capsid or HMTV. I have passed this information onto our new products team so please keep an eye on our catalgue as we may add them in the future. We do provide prim...

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