Hes1 peptide (ab126460)

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Key features and details

  • Suitable for: Blocking

Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab126460 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Hes1 antibody (ab71559)

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names

    • bHLHb39
    • C-HAIRY1
    • c-hairy1A
    • Class B basic helix-loop-helix protein 39
    • FLJ20408
    • Hairy and enhancer of split 1
    • Hairy and enhancer of split 1 (Drosophila)
    • Hairy homolog
    • Hairy homolog (Drosophila)
    • Hairy like
    • Hairy, Drosophila, homolog of
    • Hairy-like protein
    • Hairy/enhancer of split, Drosophila, homolog of, 1
    • HAIRY1
    • HES-1
    • hes1
    • Hes1 hairy and enhancer of split 1 (Drosophila)
    • HES1_HUMAN
    • HHL
    • HL
    • HRY
    • MGC129109
    • OTTHUMP00000209031
    • RHL
    • Transcription factor HES-1
    see all

  • Function

    Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity.

  • Sequence similarities

    Contains 1 basic helix-loop-helix (bHLH) domain.
    Contains 1 Orange domain.

  • Domain

    Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
    The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
    The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity.

  • Cellular localization

    Nucleus.
  • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab126460? Please let us know so that we can cite the reference in this datasheet.

ab126460 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Question

Do you sell a blocking peptide for this Hes1 antibody?

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Answer

Thank you for contacting us. I have been able to add the blocking peptide for ab71559 to our catalog. This can now be found as ab126460. I hope this helps, please let me know if you need any additional assistance.

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