Anti-HES6 antibody (ab218037)

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Overview

  • Product name

    Anti-HES6 antibody
    See all HES6 primary antibodies

  • Description

    Rabbit polyclonal to HES6

  • Host species

    Rabbit

  • Tested applications

    Suitable for: IHC-Pmore details

  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Mouse, Human

  • Immunogen

    Synthetic peptide within Human HES6 aa 10-60 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: Q96HZ4

  • Positive control

    • Rat brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab218037 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Relevance

    HES6 is a transcription cofactor that iteself does not bind to DNA but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. It also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCFEA2/E47, allowing ASCL1 and TCFEA2 to upregulate transcription in its presence. HES6 appears to have novel functions in tumour and cancer cell lines, although these have not yet been elucidated fully.

  • Cellular localization

    Nuclear

  • Database links

    see all

  • Alternative names

    • bHLHb41 antibody
    • bHLHc23 antibody
    • C HAIRY1 antibody
    • Class B basic helix-loop-helix protein 41 antibody
    • Hairy and enhancer of split 6 antibody
    • Hairy/enhancer of split 6, Drosophila, homolog of, 6 antibody
    • HES 6 antibody
    • hes family bHLH transcription factor 6 antibody
    • Transcription cofactor HES6 antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HES6 antibody (ab218037)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HES6 antibody (ab218037)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling HES6 using ab218037 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

References

ab218037 has not yet been referenced specifically in any publications.

Publishing research using ab218037? Please let us know so that we can cite the reference in this datasheet.

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