Overview

  • Product name

  • Description

    Rabbit polyclonal to HES7
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 33-63 of Human HES7.

  • Positive control

    • Mouse heart tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab102937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 25 kDa.

Target

  • Function

    Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation.
  • Involvement in disease

    Defects in HES7 are the cause of spondylocostal dysostosis type 4 (SCDO4) [MIM:613686]. A rare condition of variable severity characterized by vertebral and costal anomalies. The main feature include dwarfism, vertebral fusion, hemivertebrae, posterior rib fusion, reduced rib number, and other rib malformations.
  • Sequence similarities

    Contains 1 basic helix-loop-helix (bHLH) domain.
    Contains 1 Orange domain.
  • Domain

    Has a particular type of basic domain which includes a helix-interrupting proline.
    The C-terminal WRPW motif is a transcriptional repression motif which is necessary for interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • bHLH factor Hes7 antibody
    • bHLHb37 antibody
    • Class B basic helix loop helix protein 37 antibody
    • Class B basic helix-loop-helix protein 37 antibody
    • Hairy and enhancer of split 7 antibody
    • hes family bHLH transcription factor 7 antibody
    • Hes7 antibody
    • HES7_HUMAN antibody
    • hHes7 antibody
    • SCDO4 antibody
    • Transcription factor HES 7 antibody
    • Transcription factor HES-7 antibody
    see all

Images

  • Anti-HES7 antibody (ab102937) at 1/100 dilution + Mouse heart tissue lysate at 35 µg

    Predicted band size: 25 kDa

References

ab102937 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer

Thank you for your inquiry.

The exact immunogen sequences for these two antibodies are proprietary information. All the information I can provide is the region as it is stated on the datasheets:

ab26062: The immunogen is within theresidues 62-112 of human HES7.

ab102937: The immunogen lays within the N terminal amino acids 33-63 of Human HES7.

I am sorry that cannot provide more information on this occasion and hope this information is nevertheless helpful to your customer.

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