• Product name

  • Description

    Rabbit polyclonal to HES7
  • Host species

  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog
  • Immunogen

    Synthetic peptide within Human HES7 aa 63-112 (internal sequence). The exact sequence is proprietary.


    Database link: Q9BYE0

  • Positive control

    • Fetal human heart lysate, Human kidney and human pancreas tissue.



Our Abpromise guarantee covers the use of ab26062 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 25 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use at an assay dependent concentration.


  • Function

    Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation.
  • Involvement in disease

    Defects in HES7 are the cause of spondylocostal dysostosis type 4 (SCDO4) [MIM:613686]. A rare condition of variable severity characterized by vertebral and costal anomalies. The main feature include dwarfism, vertebral fusion, hemivertebrae, posterior rib fusion, reduced rib number, and other rib malformations.
  • Sequence similarities

    Contains 1 basic helix-loop-helix (bHLH) domain.
    Contains 1 Orange domain.
  • Domain

    Has a particular type of basic domain which includes a helix-interrupting proline.
    The C-terminal WRPW motif is a transcriptional repression motif which is necessary for interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • bHLH factor Hes7 antibody
    • bHLHb37 antibody
    • Class B basic helix loop helix protein 37 antibody
    • Class B basic helix-loop-helix protein 37 antibody
    • Hairy and enhancer of split 7 antibody
    • hes family bHLH transcription factor 7 antibody
    • Hes7 antibody
    • HES7_HUMAN antibody
    • hHes7 antibody
    • SCDO4 antibody
    • Transcription factor HES 7 antibody
    • Transcription factor HES-7 antibody
    see all


  • Anti-HES7 antibody (ab26062) at 1 µg/ml (in 5% skim milk / PBS buffer) + fetal human heart lysate

    HRP conjugated anti-Rabbit IgG

    Predicted band size: 25 kDa
    Observed band size: 25,26 kDa
    why is the actual band size different from the predicted?

    Gel concentration: 12%
  • Immunohistochemical detection of HES7 using 4 ug/ml ab26062 in paraffin embedded human kidney tissue section. Arrows indicate positively labelled epithelial cells of the renal tubule.
  • Immunohistochemical detection of HES7 using 4 ug/ml ab26062 in paraffin embedded human pancreas tissue section. Arrows indicate positively labelled epithelial cells of the pancreatic acinus.


ab26062 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A


Thank you for your inquiry.

According to the SwissProt home page (http://www.uniprot.org/uniprot/Q9BYE0) there is only one isoform.

Since I ma not experienced in the field of Transcription factor HES-7 I can only confirm that if both isoforms mentioned by your customer have the amino acids 62-112 than the antibody should recognize both.

I ma sorry that I cannot provide more detailed information on this occasion and hope that this information is nevertheless helpful for your customer.

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Thank you for your inquiry.

The exact immunogen sequences for these two antibodies are proprietary information. All the information I can provide is the region as it is stated on the datasheets:

ab26062: The immunogen is within theresidues 62-112 of human HES7.

ab102937: The immunogen lays within the N terminal amino acids 33-63 of Human HES7.

I am sorry that cannot provide more information on this occasion and hope this information is nevertheless helpful to your customer.

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