Overview

  • Product name

    HET-0016, 20-HETE synthase inhibitor
  • Description

    Potent, selective 20-HETE synthase inhibitor
  • Biological description

    Inhibits 20-HETE production (IC50 values are 18, 12 and 21 nM for CPY4A1, 4A2 and 4A3 respectively). Increases renal blood flow and inhibits cerebral ischemic damage in vivo. Crosses the blood-brain barrier.
  • Purity

    > 98%
  • CAS Number

    339068-25-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N'-(4-Butyl-2-methylphenyl)-N-hydroxymethanimidamide
  • Molecular weight

    206.30
  • Molecular formula

    C12H18N2O
  • PubChem identifier

    2727594
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCC1=CC(=C(C=C1)N=CNO)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sporková A  et al. Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats. Am J Physiol Regul Integr Comp Physiol 300:R1468-75 (2011). Read more (PubMed: 21411763) »
  • Seki T  et al. Cytochrome P450 4A isoform inhibitory profile of N-hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016), a selective inhibitor of 20-HETE synthesis. Biol Pharm Bull 28:1651-4 (2005). Read more (PubMed: 16141533) »
  • Kehl F  et al. 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. Am J Physiol Heart Circ Physiol 282:H1556-65 (2002). Read more (PubMed: 11893593) »
  • Miyata N  et al. HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme. Br J Pharmacol 133:325-9 (2001). Read more (PubMed: 11375247) »
  • Sato M  et al. Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. Bioorg Med Chem Lett 11:2993-5 (2001). Read more (PubMed: 11714595) »

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