Hexachlorophene, KCNQ1/KCNE1 potassium channel activator (ab229169)

Overview

  • Product name

    Hexachlorophene, KCNQ1/KCNE1 potassium channel activator
  • Description

    KCNQ1/KCNE1 potassium channel activator
  • Alternative names

    • HCP
    • Nabac
  • Biological description

    KCNQ1/KCNE1 potassium channel activator (EC50 of 4.61 ± 1.29 μM). Also attenuates Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation, and inhibits enoyl-acyl carrier protein reductase 

  • Purity

    > 99%
  • CAS Number

    70-30-4

Properties

  • Chemical name

    2,2'-Methylenebis[3,4,6-trichlorophenol]
  • Molecular weight

    406.90
  • Molecular formula

    C13H6Cl6O2
  • PubChem identifier

    3598
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl
  • Source

    Synthetic

References

This product has been referenced in:

  • Zheng Y  et al. Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants. PLoS One 7:e51820 (2012). Read more (PubMed: 23251633) »
  • Park S  et al. Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. Mol Pharmacol 70:960-6 (2006). Read more (PubMed: 16735606) »
  • Heath RJ  et al. Inhibition of the Staphylococcus aureus NADPH-dependent enoyl-acyl carrier protein reductase by triclosan and hexachlorophene. J Biol Chem 275:4654-9 (2000). Read more (PubMed: 10671494) »

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