Hexamethylene bisacetamide (HMBA), cell differentiation inducer (ab142438)

Overview

  • Product name

    Hexamethylene bisacetamide (HMBA), cell differentiation inducer
  • Description

    Cell differentiation inducer
  • Biological description

    Cell differentiation inducer. Inhibits activation of NF-kappaB function, Akt and ERK/MAPK cascade. Sensitizes cells to apoptosis in vitro. Induces cells to differentiate into nomal or benign cells in vivo. Antitumor and hematinic agent. Orally active. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    3073-59-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Chatzopoulou M  et al. Bis-pyrrolyl-tetrazolyl derivatives as hybrid polar compounds: A case of lipophilic functional bioisosterism with bis-acetamides. Eur J Med Chem 50:75-80 (2012). Read more (PubMed: 22341896) »
  • Dey A  et al. Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF kappaB activity: implications for cancer therapy. Cell Cycle 7:3759-67 (2008). Read more (PubMed: 19029824) »
  • Jia B  et al. [Differentiation effect of hexamethylene bisacetamide (HMBA) on mucoepidermoid carcinoma in vivo]. Zhonghua Kou Qiang Yi Xue Za Zhi 31:85-7 (1996). Read more (PubMed: 9387538) »
  • Reuben RC Studies on the mechanism of action of hexamethylene bisacetamide, a potent inducer of erythroleukemic differentiation. Biochim Biophys Acta 588:310-21 (1979). Read more (PubMed: 292456) »

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