Key features and details
- Rabbit polyclonal to HEXB - C-terminal
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-HEXB antibody - C-terminal
See all HEXB primary antibodies
DescriptionRabbit polyclonal to HEXB - C-terminal
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Synthetic peptide derived from the C terminus of Human HEXB.
- Human brain cortex tissue; Jurkat cell extract.
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Storage instructionsShipped at 4°C. Store at -20ºC.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 49% PBS, 0.88% Sodium chloride
PBS without Mg2+ and Ca2+.
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab166791 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 63 kDa.|
|IHC-P||Use a concentration of 5 µg/ml.|
FunctionResponsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.
Involvement in diseaseDefects in HEXB are the cause of GM2-gangliosidosis type 2 (GM2G2) [MIM:268800]; also known as Sandhoff disease. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2G2 is clinically indistinguishable from GM2-gangliosidosis type 1, presenting startle reactions, early blindness, progressive motor and mental deterioration, macrocephaly and cherry-red spots on the macula.
Sequence similaritiesBelongs to the glycosyl hydrolase 20 family.
modificationsN-linked glycans at Asn-142 and Asn-190 consist of Man(3)-GlcNAc(2) and Man(5 to 7)-GlcNAc(2), respectively.
The beta-A and beta-B chains are produced by proteolytic processing of the precursor beta chain.
- Information by UniProt
- Beta hexosaminidase beta chain antibody
- Beta hexosaminidase subunit beta antibody
- Beta N acetylhexosaminidase antibody
All lanes : Anti-HEXB antibody - C-terminal (ab166791) at 1/500 dilution
Lane 1 : Jurkat cell extract
Lane 2 : Jurkat cell extract with immunizing peptide
Predicted band size: 63 kDa
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain cortex tissue labeling HEXB with ab166791 at 5 µg/ml.
ab166791 has not yet been referenced specifically in any publications.