Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific.
Carbohydrate metabolism; hexose metabolism.
Involvement in disease
Hexokinase deficiency Neuropathy, hereditary motor and sensory, Russe type
Belongs to the hexokinase family. Contains 2 hexokinase domains.
The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule.
Mitochondrion outer membrane. Its hydrophobic N-terminal sequence may be involved in membrane binding.