Key features and details
- Sheep polyclonal to HHV8 ORF62
- Suitable for: WB
- Reacts with: Species independent
- Isotype: IgG
Product nameAnti-HHV8 ORF62 antibody
DescriptionSheep polyclonal to HHV8 ORF62
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Species independent
Fusion protein that contains at its amino terminus the maltose binding protein (mal 62) and at its carboxy terminus the protein encoded by the Open reading frame 62 (ORF 62). ORF 62 interacts with the minor capsid protein of HHV8 and mediates its translocation to the nucleus where the assembly of the HHV8 capsid components take place.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: 0.08% Sodium azide
Concentration information loading...
PurityProtein G purified
Purification notesThis antibody is provided as a 0.2µm sterile filtered solution.
Our Abpromise guarantee covers the use of ab16159 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
RelevanceKaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17), the major capsid protein (encoded by ORF25), and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65). Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23.
- HHV8 antibody
- Human herpes virus 8 antibody
- Kaposi's sarcoma associated herpesvirus antibody
ab16159 has been referenced in 1 publication.
- Lin X et al. MicroRNAs and unusual small RNAs discovered in Kaposi's sarcoma-associated herpesvirus virions. J Virol 86:12717-30 (2012). PubMed: 22973026