Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.02% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.4
Concentration information loading...
PurityImmunogen affinity purified
Immunizing Peptide (Blocking)
|ELISA||Use at an assay dependent concentration. This antibody gave a positive result in ELISA against the immunizing peptide (ab33028). Not yet tested in other applications.|
FunctionTranscriptional repressor. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall.
Tissue specificityUbiquitously expressed with highest levels found in lung, colon, prostate, thymus, testis and ovary. Expression is absent or decreased in many tumor cells.
Sequence similaritiesBelongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
Contains 1 BTB (POZ) domain.
Contains 5 C2H2-type zinc fingers.
modificationsAcetylated on several residues, including Lys-333. Lys-333 is deacetylated by SIRT1.
Sumoylated on Lys-333 by a PIAS family member, which positively regulates transcriptional repression ativity and is enhanced by HDAC4.
- Information by UniProt
- Hic 1 antibody
- HIC ZBTB transcriptional repressor 1 antibody
- Hic-1 antibody
This product has been referenced in:
- Janeckova L et al. HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy. Transl Oncol 9:99-107 (2016). IHC . Read more (PubMed: 27084425) »
- Yu DH et al. Developmentally programmed 3' CpG island methylation confers tissue- and cell-type-specific transcriptional activation. Mol Cell Biol 33:1845-58 (2013). Read more (PubMed: 23459939) »