Anti-HIF-1 alpha antibody [H1alpha67] - ChIP Grade (ab1)

Mouse monoclonal HIF-1 alpha antibody [H1alpha67]. Validated in WB, IP, IHC, Flow Cyt, ChIP, ICC/IF and tested in Mouse, Rat, Human. Cited in 116 publication(s). Independently reviewed in 42 review(s)

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ab1 has been referenced in 124 publications.

  • Jin F  et al. HIF-1a-induced miR-23a~27a~24 cluster promotes colorectal cancer progression via reprogramming metabolism. Cancer Lett 440-441:211-222 (2019). PubMed: 30393198
  • Xu W  et al. Hypoxia changes chemotaxis behaviour of mesenchymal stem cells via HIF-1a signalling. J Cell Mol Med 23:1899-1907 (2019). PubMed: 30628201
  • Zhang F & Zhang M Oleuropein inhibits esophageal cancer through hypoxic suppression of BTG3 mRNA. Food Funct 10:978-985 (2019). PubMed: 30702111
  • Wang C  et al. SENP1 Interacts with HIF1a to Regulate Glycolysis of Prostatic Carcinoma Cells. Int J Biol Sci 15:395-403 (2019). PubMed: 30745829
  • Xu S  et al. CXCR7 promotes melanoma tumorigenesis via Src kinase signaling. Cell Death Dis 10:191 (2019). PubMed: 30804329
  • Sakai Y  et al. Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells. Sci Rep 9:2799 (2019). PubMed: 30808980
  • Luo G  et al. Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress. Int J Mol Med 43:2033-2043 (2019). PubMed: 30864731
  • Du F  et al. SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis. Cell Death Dis 10:239 (2019). PubMed: 30858360
  • Cai CC  et al. Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway. Oxid Med Cell Longev 2019:4248529 (2019). PubMed: 30881590
  • Hulse M  et al. Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1. PLoS Pathog 14:e1007394 (2018). PubMed: 30395643
  • Fong LY  et al. Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats. Proc Natl Acad Sci U S A 115:E11091-E11100 (2018). PubMed: 30397150
  • Yang X & Zi XH LncRNA SNHG1 alleviates OGD induced injury in BMEC via miR-338/HIF-1a axis. Brain Res N/A:N/A (2018). PubMed: 30414401
  • Dho SH  et al. Development of a radionuclide-labeled monoclonal anti-CD55 antibody with theranostic potential in pleural metastatic lung cancer. Sci Rep 8:8960 (2018). PubMed: 29895866
  • Ferri A  et al. Tissue specificity of mitochondrial adaptations in rats after 4 weeks of normobaric hypoxia. Eur J Appl Physiol N/A:N/A (2018). PubMed: 29855791
  • Li S  et al. Mechanism and prognostic value of indoleamine 2,3-dioxygenase 1 expressed in hepatocellular carcinoma. Cancer Sci 109:3726-3736 (2018). PubMed: 30264546
  • Zhou H  et al. Mechanism and therapeutic effects of Saccharomyces boulardii on experimental colitis in mice. Mol Med Rep 18:5652-5662 (2018). PubMed: 30387820
  • Chen X  et al. Proteomics-based investigation of multiple stages of OSCC development indicates that the inhibition of Trx-1 delays oral malignant transformation. Int J Oncol 52:733-742 (2018). PubMed: 29328386
  • Leng J  et al. miR-15a represses cancer cell migration and invasion under conditions of hypoxia by targeting and downregulating Bcl-2 expression in human osteosarcoma cells. Int J Oncol 52:1095-1104 (2018). PubMed: 29484432
  • Frenzel T  et al. Locally Ablative Radiation Therapy of a Primary Human Small Cell Lung Cancer Tumor Decreases the Number of Spontaneous Metastases in Two Xenograft Models. Int J Radiat Oncol Biol Phys 100:1044-1056 (2018). PubMed: 29485046
  • Hwang S  et al. Hypoxia regulates the level of glutamic acid decarboxylase enzymes and interrupts inhibitory synapse stability in primary cultured neurons. Neurotoxicology 65:221-230 (2018). WB . PubMed: 29107683
  • Li X  et al. Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling. Mol Cell Proteomics 16:594-607 (2017). PubMed: 28174230
  • Gomes de Castro MA  et al. Aptamers provide superior stainings of cellular receptors studied under super-resolution microscopy. PLoS One 12:e0173050 (2017). PubMed: 28235049
  • Oh TI  et al. Fascaplysin Exerts Anti-Cancer Effects through the Downregulation of Survivin and HIF-1a and Inhibition of VEGFR2 and TRKA. Int J Mol Sci 18:N/A (2017). PubMed: 28961193
  • Kobayashi M  et al. A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1a to promoter regions of its downstream genes. FEBS J 284:3804-3816 (2017). PubMed: 28963769
  • Wang M  et al. HIF-1a promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment. J Exp Clin Cancer Res 36:60 (2017). WB ; Human . PubMed: 28449718
  • Kuang R  et al. GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance. JCI Insight 2:e88815 (2017). WB ; Human . PubMed: 28138554
  • Lv B  et al. Hypoxia inducible factor 1a promotes survival of mesenchymal stem cells under hypoxia. Am J Transl Res 9:1521-1529 (2017). WB ; Rat . PubMed: 28386377
  • Ciria M  et al. Mesenchymal Stem Cell Migration and Proliferation Are Mediated by Hypoxia-Inducible Factor-1a Upstream of Notch and SUMO Pathways. Stem Cells Dev 26:973-985 (2017). WB ; Human . PubMed: 28520516
  • Opinto G  et al. Hierarchical clustering analysis identifies metastatic colorectal cancers patients with more aggressive phenotype. Oncotarget 8:87782-87794 (2017). IHC-P ; Human . PubMed: 29152120
  • Guo X  et al. Macrophage migration inhibitory factor promotes vasculogenic mimicry formation induced by hypoxia via CXCR4/AKT/EMT pathway in human glioblastoma cells. Oncotarget 8:80358-80372 (2017). PubMed: 29113309
  • Diao S  et al. Trefoil factor 3 contributes to the malignancy of glioma via regulating HIF-1a. Oncotarget 8:76770-76782 (2017). PubMed: 29100347
  • Chen PC  et al. CCN3 promotes epithelial-mesenchymal transition in prostate cancer via FAK/Akt/HIF-1a-induced twist expression. Oncotarget 8:74506-74518 (2017). PubMed: 29088803
  • Hanouna G  et al. Specific calpain inhibition protects kidney against inflammaging. Sci Rep 7:8016 (2017). PubMed: 28808241
  • Martín-Aragón Baudel MAS  et al. Preferential activation of HIF-2a adaptive signalling in neuronal-like cells in response to acute hypoxia. PLoS One 12:e0185664 (2017). PubMed: 28968430
  • Sturla LM  et al. Aspartate-ß-hydroxylase (ASPH): A potential therapeutic target in human malignant gliomas. Heliyon 2:e00203 (2016). IHC ; Human . PubMed: 27981247
  • Li X  et al. Hypoxia-induced lncRNA-NUTF2P3-001 contributes to tumorigenesis of pancreatic cancer by derepressing the miR-3923/KRAS pathway. Oncotarget 7:6000-14 (2016). WB, ChIP ; Human . PubMed: 26755660
  • Zhu ZH  et al. Dimethyloxaloylglycine increases bone repair capacity of adipose-derived stem cells in the treatment of osteonecrosis of the femoral head. Exp Ther Med 12:2843-2850 (2016). WB ; Rabbit . PubMed: 27882083
  • Belton M  et al. Hypoxia and tissue destruction in pulmonary TB. Thorax 71:1145-1153 (2016). IHC-P ; Human . PubMed: 27245780
  • Asci H  et al. Protective effects of aspirin and vitamin C against corn syrup consumption-induced cardiac damage through sirtuin-1 and HIF-1a pathway. Anatol J Cardiol 16:648-54 (2016). PubMed: 26645266
  • Ye LY  et al. Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis. Cancer Res 76:818-30 (2016). PubMed: 26837767
  • Cherepanova OA  et al. Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. Nat Med 22:657-65 (2016). PubMed: 27183216
  • Choi YJ  et al. The resveratrol analog HS-1793 enhances radiosensitivity of mouse-derived breast cancer cells under hypoxic conditions. Int J Oncol 49:1479-88 (2016). PubMed: 27498957
  • Miroshnikova YA  et al. Tissue mechanics promote IDH1-dependent HIF1a-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol 18:1336-1345 (2016). PubMed: 27820599
  • Vodicka P  et al. Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice. J Huntingtons Dis 5:249-260 (2016). PubMed: 27689619
  • Eisch V  et al. Progerin impairs chromosome maintenance by depleting CENP-F from metaphase kinetochores in Hutchinson-Gilford progeria fibroblasts. Oncotarget 7:24700-18 (2016). WB, ICC . PubMed: 27015553
  • Wu L  et al. Expression and contribution of the HIF-1a/VEGF signaling pathway to luteal development and function in pregnant rats. Mol Med Rep 12:7153-9 (2015). PubMed: 26323652
  • Singh SP  et al. HIF-1a Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice. PLoS One 10:e0137757 (2015). WB ; Mouse . PubMed: 26361040
  • de Brito Alves JL  et al. Maternal protein restriction increases respiratory and sympathetic activities and sensitizes peripheral chemoreflex in male rat offspring. J Nutr 145:907-14 (2015). WB ; Rat . PubMed: 25934662
  • Xiao H  et al. ?-H2AX promotes hepatocellular carcinoma angiogenesis via EGFR/HIF-1a/VEGF pathways under hypoxic condition. Oncotarget 6:2180-92 (2015). Human . PubMed: 25537504
  • Sazonova O  et al. Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet 11:e1005202 (2015). ChIP . PubMed: 26020271
  • Sato M  et al. LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells. Mol Med Rep 12:3462-8 (2015). ICC/IF ; Human . PubMed: 26017562
  • Iwasaki K  et al. Role of hypoxia-inducible factor-1a, carbonic anhydrase-IX, glucose transporter-1 and vascular endothelial growth factor associated with lymph node metastasis and recurrence in patients with locally advanced cervical cancer. Oncol Lett 10:1970-1978 (2015). IHC-P ; Human . PubMed: 26622782
  • Kim BH  et al. Imidazole-based alkaloid derivative LCB54-0009 suppresses ocular angiogenesis and lymphangiogenesis in models of experimental retinopathy and corneal neovascularization. Br J Pharmacol 172:3875-89 (2015). WB . PubMed: 25917462
  • Vavilala DT  et al. Evaluation of anti-HIF and anti-angiogenic properties of honokiol for the treatment of ocular neovascular diseases. PLoS One 9:e113717 (2014). WB, IF, ChIP ; Human . PubMed: 25422886
  • Ekman M  et al. HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition. Lab Invest 94:557-68 (2014). Rat . PubMed: 24589856
  • Auffinger B  et al. Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy. Cell Death Differ 21:1119-31 (2014). Human . PubMed: 24608791
  • Moussa M  et al. Nanodrug-enhanced radiofrequency tumor ablation: effect of micellar or liposomal carrier on drug delivery and treatment efficacy. PLoS One 9:e102727 (2014). IHC-P ; Rat . PubMed: 25133740
  • Katare R  et al. Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia. Arterioscler Thromb Vasc Biol 34:408-18 (2014). PubMed: 24202301
  • Tanaka Y  et al. BIMEL is a key effector molecule in oxidative stress-mediated apoptosis in acute myeloid leukemia cells when combined with arsenic trioxide and buthionine sulfoximine. BMC Cancer 14:27 (2014). PubMed: 24428916
  • Sadlecki P  et al. The role of Hypoxia-inducible factor-1 a , glucose transporter-1, (GLUT-1) and carbon anhydrase IX in endometrial cancer patients. Biomed Res Int 2014:616850 (2014). IHC-P ; Human . PubMed: 24745019
  • Hervé V  et al. VEGF neutralizing aerosol therapy in primary pulmonary adenocarcinoma with K-ras activating-mutations. MAbs 6:1638-48 (2014). IHC-P ; Mouse . PubMed: 25484066
  • Yamashita A  et al. Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage. PLoS One 9:e86426 (2014). IHC-P ; Rabbit . PubMed: 24466087
  • Mojic M  et al. Extracellular iron diminishes anticancer effects of vitamin C: an in vitro study. Sci Rep 4:5955 (2014). ICC/IF ; Human . PubMed: 25092529
  • Zhang D  et al. The N-terminal region of p27 inhibits HIF-1a protein translation in ribosomal protein S6-dependent manner by regulating PHLPP-Ras-ERK-p90RSK axis. Cell Death Dis 5:e1535 (2014). ICC ; Mouse . PubMed: 25412313
  • Antelmi E  et al. ß1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion. PLoS One 8:e75113 (2013). WB, IHC-P ; Human . PubMed: 24086451
  • Ward CL  et al. Oxygen generating biomaterials preserve skeletal muscle homeostasis under hypoxic and ischemic conditions. PLoS One 8:e72485 (2013). IHC-Fr ; Rat . PubMed: 23991116
  • Ferguson BJ  et al. Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence. J Gen Virol 94:2070-81 (2013). WB . PubMed: 23761407
  • Harrison H  et al. Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-a status. Cancer Res 73:1420-33 (2013). IHC ; Human . PubMed: 23248117
  • Tripathy D  et al. Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia. Front Aging Neurosci 5:19 (2013). IHC-P ; Mouse . PubMed: 23675346
  • Lan X  et al. High glucose enhances HIV entry into T cells through upregulation of CXCR4. J Leukoc Biol 94:769-77 (2013). Human . PubMed: 23911867
  • Velpula KK  et al. Combined targeting of PDK1 and EGFR triggers regression of glioblastoma by reversing the Warburg effect. Cancer Res 73:7277-89 (2013). PubMed: 24148623
  • Carrière M  et al. HIV "Elite Controllers" Are Characterized by a High Frequency of Memory CD8+CD73+ T Cells Involved in the Antigen-Specific CD8+ T-cell Response. J Infect Dis N/A:N/A (2013). Human . PubMed: 24357632
  • Li J  et al. Intrinsic indicators for specimen degradation. Lab Invest 93:242-53 (2013). PubMed: 23212099
  • Flisinski M  et al. Decreased hypoxia-inducible factor-1a in gastrocnemius muscle in rats with chronic kidney disease. Kidney Blood Press Res 35:608-18 (2012). PubMed: 22948748
  • Eckle T  et al. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med 18:774-82 (2012). WB . PubMed: 22504483
  • Elias I  et al. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes 61:1801-13 (2012). WB ; Mouse . PubMed: 22522611
  • Bensellam M  et al. Glucose-induced O2 consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells. PLoS One 7:e29807 (2012). WB . PubMed: 22235342
  • Paatero I  et al. Interaction with ErbB4 promotes hypoxia-inducible factor-1a signaling. J Biol Chem 287:9659-71 (2012). IHC-P ; Mouse . PubMed: 22308027
  • Yoon BC  et al. Local translation of extranuclear lamin B promotes axon maintenance. Cell 148:752-64 (2012). IF . PubMed: 22341447
  • Bryant PE  et al. Topoisomerase IIa levels and G2 radiosensitivity in T-lymphocytes of women presenting with breast cancer. Mutagenesis 27:737-41 (2012). PubMed: 22935224
  • Veikkolainen V  et al. ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol 23:112-22 (2012). IHC-P ; Mouse . PubMed: 22076439
  • Ciuclan L  et al. A novel murine model of severe pulmonary arterial hypertension. Am J Respir Crit Care Med 184:1171-82 (2011). WB ; Mouse . PubMed: 21868504
  • Hempel C  et al. CNS hypoxia is more pronounced in murine cerebral than noncerebral malaria and is reversed by erythropoietin. Am J Pathol 179:1939-50 (2011). IHC-P ; Mouse . PubMed: 21854739
  • Grammas P  et al. Brain microvasculature and hypoxia-related proteins in Alzheimer's disease. Int J Clin Exp Pathol 4:616-27 (2011). WB ; Rat . PubMed: 21904637
  • Ingraham CA  et al. Matrix Metalloproteinase (MMP)-9 Induced by Wnt Signaling Increases the Proliferation and Migration of Embryonic Neural Stem Cells at Low O2 Levels. J Biol Chem 286:17649-57 (2011). WB ; Rat . PubMed: 21460212
  • Bento CF  et al. Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction. Exp Physiol 95:955-70 (2010). WB, IHC-Fr ; Human, Rat . PubMed: 20562294
  • Pereira ER  et al. Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein response. PLoS One 5: (2010). WB ; Rat . PubMed: 20824063
  • Itoigawa Y  et al. Hypoxia induces adipogenic differentitation of myoblastic cell lines. Biochem Biophys Res Commun 399:721-6 (2010). WB ; Mouse . PubMed: 20692234
  • Viñas-Castells R  et al. The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. J Biol Chem 285:3794-805 (2010). WB ; Mouse, Human . PubMed: 19955572
  • Fisher CD  et al. Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. Drug Metab Dispos 37:2087-94 (2009). PubMed: 19651758
  • Bailey JM  et al. Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene 28:3513-25 (2009). WB . PubMed: 19633682
  • Chiacchiera F  et al. p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription. Cell Death Differ 16:1203-14 (2009). WB ; Human . PubMed: 19343039
  • Sasaki R  et al. Oncogenic transformation of human ovarian surface epithelial cells with defined cellular oncogenes. Carcinogenesis 30:423-31 (2009). WB . PubMed: 19126650
  • Sanduja S  et al. The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase. Aging (Albany NY) 1:803-17 (2009). PubMed: 20157568
  • Jensen ED  et al. Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner. J Bone Miner Res 23:361-72 (2008). PubMed: 17997710
  • Walczak-Drzewiecka A  et al. HIF-1alpha is up-regulated in activated mast cells by a process that involves calcineurin and NFAT. J Immunol 181:1665-72 (2008). WB ; Human . PubMed: 18641302
  • Kane R  et al. Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. Mol Vis 14:1138-48 (2008). WB ; Human . PubMed: 18587495
  • Laurent G  et al. Oxidative stress contributes to aging by enhancing pancreatic angiogenesis and insulin signaling. Cell Metab 7:113-24 (2008). IHC ; Mouse . PubMed: 18249171
  • Svensson KJ  et al. Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase. Cancer Res 68:9291-301 (2008). PubMed: 19010902
  • Ye J  et al. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293:E1118-28 (2007). Mouse . PubMed: 17666485
  • Natarajan R  et al. Activation of hypoxia-inducible factor-1 via prolyl-4 hydoxylase-2 gene silencing attenuates acute inflammatory responses in postischemic myocardium. Am J Physiol Heart Circ Physiol 293:H1571-80 (2007). PubMed: 17545479
  • Natarajan R  et al. Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury. Circ Res 98:133-40 (2006). PubMed: 16306444
  • Critchley HO  et al. Hypoxia-inducible factor-1alpha expression in human endometrium and its regulation by prostaglandin E-series prostanoid receptor 2 (EP2). Endocrinology 147:744-53 (2006). PubMed: 16282352
  • Pisani DF  et al. SMHS1 is involved in oxidative/glycolytic-energy metabolism balance of muscle fibers. Biochem Biophys Res Commun 326:788-93 (2005). PubMed: 15607738
  • Bos R  et al. Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer. Histopathology 46:31-6 (2005). PubMed: 15656883
  • Berger AP  et al. Increased growth factor production in a human prostatic stromal cell culture model caused by hypoxia. Prostate 57:57-65 (2003). PubMed: 12886524
  • Coradini D  et al. Infiltrating ductal and lobular breast carcinomas are characterised by different interrelationships among markers related to angiogenesis and hormone dependence. Br J Cancer 87:1105-11 (2002). PubMed: 12402149
  • Haugland HK  et al. Expression of hypoxia-inducible factor-1alpha in cervical carcinomas: correlation with tumor oxygenation. Int J Radiat Oncol Biol Phys 53:854-61 (2002). PubMed: 12095550
  • Gardner LB  et al. Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem 276:7919-26 (2001). PubMed: 11112789
  • Yu F  et al. Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein. Cancer Res 61:4136-42 (2001). PubMed: 11358837
  • Schindl M  et al. DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance. Int J Oncol 19:799-802 (2001). PubMed: 11562758
  • Itoh T  et al. Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane. FEBS Lett 509:225-9 (2001). PubMed: 11741593
  • Duyndam MC  et al. Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. J Biol Chem 276:48066-76 (2001). PubMed: 11641398
  • Volm M & Koomägi R Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res 20:1527-33 (2000). PubMed: 10928066
  • Palmer LA  et al. Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides. Mol Pharmacol 58:1197-203 (2000). PubMed: 11093754
  • Ravi R  et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 14:34-44 (2000). PubMed: 10640274
  • Zhong H  et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60:1541-5 (2000). PubMed: 10749120
  • Rivard A  et al. Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity. J Biol Chem 275:29643-7 (2000). PubMed: 10882714
  • Chandel NS  et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem 275:25130-8 (2000). PubMed: 10833514
  • Agani FH  et al. The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. J Biol Chem 275:35863-7 (2000). PubMed: 10961998
  • Birner P  et al. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 60:4693-6 (2000). PubMed: 10987269
  • Feldser D  et al. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res 59:3915-8 (1999). PubMed: 10463582
  • Nguyen SV & Claycomb WC Hypoxia regulates the expression of the adrenomedullin and HIF-1 genes in cultured HL-1 cardiomyocytes. Biochem Biophys Res Commun 265:382-6 (1999). PubMed: 10558876
  • Zhong H  et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59:5830-5 (1999). PubMed: 10582706

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