Overview

  • Product name

    Histamine phosphate
  • Description

    Phosphate salt of Histamine (ab146241). Acts as a neurotransmitter in the nervous system and as a local mediator in the gut, skin, and immune system
  • Alternative names

    • 2-(4-Imidazolyl)ethylamine phosphate
  • Biological description

    Phosphate salt of Histamine (ab146241). Acts as a neurotransmitter in the nervous system and as a local mediator in the gut, skin, and immune system. Brings about complex physiologic changes, including neurotransmission, inflammation, smooth muscle contraction, dilatation of capillaries, chemotaxis, cytokine production, and gastric acid secretion. These biologic changes occur primarily by binding to G protein-coupled histamine receptors (H1 receptor, H2 receptor, H3 receptor, and H4 receptor).

  • Purity

    > 99%
  • CAS Number

    51-74-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1H-Imidazole-4-ethanamine phosphate
  • Molecular weight

    307.14
  • Molecular formula

    C5H9N.2H3O4P
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Panula P  et al. International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. Pharmacol Rev 67:601-55 (2015). Read more (PubMed: 26084539) »
  • Tremblay C  et al. Histamine phosphate has a cumulative effect when inhaled at five minute intervals. Thorax 39:946-51 (1984). Read more (PubMed: 6515599) »

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