Anti-Histone acetyltransferase MYST3 antibody - C-terminal (ab170568)

Overview

  • Product name
    Anti-Histone acetyltransferase MYST3 antibody - C-terminal
    See all Histone acetyltransferase MYST3 primary antibodies
  • Description
    Rabbit polyclonal to Histone acetyltransferase MYST3 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide within Human Histone acetyltransferase MYST3 aa 1318-1351 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q92794

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Ammonium Sulphate Precipitation
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab170568 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Predicted molecular weight: 225 kDa.

Target

  • Function
    Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.
  • Involvement in disease
    Note=Chromosomal aberrations involving MYST3 may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/MOZ and the C-terminus part of NCOA2/TIF2. MYST3-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
    Note=A chromosomal aberration involving MYST3 is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a MYST3-ASXL2 fusion protein.
  • Sequence similarities
    Belongs to the MYST (SAS/MOZ) family.
    Contains 1 C2HC-type zinc finger.
    Contains 1 H15 (linker histone H1/H5 globular) domain.
    Contains 2 PHD-type zinc fingers.
  • Domain
    The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.
  • Post-translational
    modifications
    Autoacetylated.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus. Partially concentrated in subnuclear foci distinct from PML bodies, and excluded from the nucleoli.
  • Information by UniProt
  • Database links
  • Alternative names
    • HAT 3 antibody
    • Histone acetyltransferase MYST3 antibody
    • Monocytic leukemia zinc finger protein antibody
    • MOZ antibody
    • MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3 antibody
    • MYST histone acetyltransferase (monocytic leukemia) 3 antibody
    • MYST protein 3 antibody
    • MYST-3 antibody
    • MYST3 antibody
    • MYST3_HUMAN antibody
    • OTTHUMP00000197392 antibody
    • OTTHUMP00000197394 antibody
    • OTTHUMP00000225722 antibody
    • Runt related transcription factor binding protein 2 antibody
    • Runt-related transcription factor-binding protein 2 antibody
    • RUNXBP2 antibody
    • SAS2 antibody
    • SAS2 and TIP60 protein 3 antibody
    • TIP60 protein 3 antibody
    • YBF2/SAS3 antibody
    • ZC2HC6A antibody
    • Zinc finger protein 220 antibody
    • ZNF220 antibody
    see all

Images

  • Anti-Histone acetyltransferase MYST3 antibody - C-terminal (ab170568) at 1/100 dilution + Mouse stomach tissue lysate at 35 µg

    Predicted band size: 225 kDa

References

ab170568 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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