Key features and details
- Rabbit polyclonal to Histone acetyltransferase MYST3/MOZ
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Histone acetyltransferase MYST3/MOZ antibody
See all Histone acetyltransferase MYST3/MOZ primary antibodies
DescriptionRabbit polyclonal to Histone acetyltransferase MYST3/MOZ
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human Histone acetyltransferase MYST3/MOZ (C terminal).
Previously labelled as Histone acetyltransferase MYST3.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: 0.02% Thimerosal (merthiolate)
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Concentration information loading...
PurityProtein A purified
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionHistone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.
Involvement in diseaseNote=Chromosomal aberrations involving MYST3 may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/MOZ and the C-terminus part of NCOA2/TIF2. MYST3-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
Note=A chromosomal aberration involving MYST3 is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a MYST3-ASXL2 fusion protein.
Sequence similaritiesBelongs to the MYST (SAS/MOZ) family.
Contains 1 C2HC-type zinc finger.
Contains 1 H15 (linker histone H1/H5 globular) domain.
Contains 2 PHD-type zinc fingers.
DomainThe N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationNucleus. Partially concentrated in subnuclear foci distinct from PML bodies, and excluded from the nucleoli.
- Information by UniProt
- HAT 3 antibody
- Histone acetyltransferase MYST3 antibody
- Monocytic leukemia zinc finger protein antibody
ab41718 has been referenced in 3 publications.
- Xiong X et al. Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2. Nat Chem Biol 12:1111-1118 (2016). PubMed: 27775714
- Perez-Campo FM et al. MOZ-mediated repression of p16(INK) (4) (a) is critical for the self-renewal of neural and hematopoietic stem cells. Stem Cells 32:1591-601 (2014). ChIP . PubMed: 24307508
- Paggetti J et al. Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells. Oncogene 29:5019-31 (2010). WB ; Human . PubMed: 20581860