Overview

  • Product name

    Anti-Histone H1.1 antibody
    See all Histone H1.1 primary antibodies
  • Description

    Rabbit polyclonal to Histone H1.1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human Histone H1.1 (internal sequence). The exact sequence is proprietary.
    Database link: Q02539

  • Positive control

    • Jurkat whole cell and nuclear extract lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab229124 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 22 kDa.

Target

  • Relevance

    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo. The C-terminal region also shows the most differences in aa sequence between the H1 histone variants H1.0/1/2/3/4/5.
  • Cellular localization

    Nuclear
  • Database links

  • Alternative names

    • H1 histone family member 1 antibody
    • H1.1 antibody
    • H1F1 antibody
    • HIST1 antibody
    • HIST1H1A antibody
    • Histone 1 H1a antibody
    • Histone cluster 1 H1a antibody
    see all

Images

  • All lanes : Anti-Histone H1.1 antibody (ab229124) at 1/1000 dilution

    Lane 1 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate
    Lane 2 : Jurkat (human T cell leukemia cell line from peripheral blood) nuclear lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 22 kDa



    15% SDS-PAGE gel.

References

ab229124 has not yet been referenced specifically in any publications.

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