Key features and details
- Rabbit polyclonal to Histone H1oo
- Suitable for: IHC-P, WB
- Reacts with: Mouse
- Isotype: IgG
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferConstituent: Whole serum
Concentration information loading...
Our Abpromise guarantee covers the use of ab71580 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use at an assay dependent concentration.|
|WB||1/200 - 1/2000. Predicted molecular weight: 32 kDa.|
FunctionMay play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling.
Sequence similaritiesBelongs to the histone H1/H5 family.
Contains 1 H15 (linker histone H1/H5 globular) domain.
Cellular localizationCytoplasm. Nucleus. Chromosome.
- Information by UniProt
- H1 histone family member O oocyte specific antibody
- H1FOO antibody
- H1FOO_HUMAN antibody
ab71580 has been referenced in 3 publications.
- Li Z et al. Huangqi decoction inhibits hyperglycemia-induced podocyte apoptosis by down-regulated Nox4/p53/Bax signaling in vitro and in vivo. Am J Transl Res 11:3195-3212 (2019). PubMed: 31217889
- Funaya S et al. Linker histone H1FOO regulates the chromatin structure in mouse zygotes. FEBS Lett 592:2414-2424 (2018). PubMed: 29963710
- Hou J et al. Liraglutide, a long-acting GLP-1 mimetic, and its metabolite attenuate inflammation after intracerebral hemorrhage. J Cereb Blood Flow Metab 32:2201-10 (2012). PubMed: 22968320