Key features and details
- Goat polyclonal to HIV1 gp120
- Suitable for: ELISA, WB
- Reacts with: Species independent
- Isotype: IgG
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.1% Sodium azide
Constituent: 0.0268% PBS
Concentration information loading...
Purification notesPurified by Sodium sulfate precipitation and ion-exchange chromatography. >95% pure.
Our Abpromise guarantee covers the use of ab21179 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||Use at an assay dependent concentration.|
|WB||1/1000. Predicted molecular weight: 120 kDa. Dilution optimised using Chromogenic detection|
RelevanceHIV1 is equipped with the envelope gp160 glycoprotein for interaction with Langerhans cells (LCs) and dendritic cells (DCs), the members of the innate immune system, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of T helper 2 (Th2) cells, and is able to induce FcepsilonRI(+) hematopoietic cells to produce IL4, which inactivates the host adaptive immune response.
Cellular localizationEnvelope surface glycoprotein.
- Glycoprotein 120 antibody
- gp120 antibody
- SU antibody
- Surface protein antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab21179 has been referenced in 19 publications.
- Giel-Moloney M et al. Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector. Sci Rep 9:20005 (2019). PubMed: 31882800
- Domljanovic I et al. Complexes of DNA with fluorescent dyes are effective reagents for detection of autoimmune antibodies. Sci Rep 7:1925 (2017). PubMed: 28507286
- Safavieh M et al. Paper microchip with a graphene-modified silver nano-composite electrode for electrical sensing of microbial pathogens. Nanoscale 9:1852-1861 (2017). PubMed: 27845796
- Zheng W et al. Conserved Interaction of Lentiviral Vif Molecules with HIV-1 Gag and Differential Effects of Species-Specific Vif on Virus Production. J Virol 91:N/A (2017). PubMed: 28122978
- Saito H et al. N-terminally truncated POM121C inhibits HIV-1 replication. PLoS One 12:e0182434 (2017). PubMed: 28873410