Anti-HIV1 gp120 antibody (ab21179)
Key features and details
- Goat polyclonal to HIV1 gp120
- Suitable for: ELISA, WB
- Reacts with: Species independent
- Isotype: IgG
Overview
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Product name
Anti-HIV1 gp120 antibody
See all HIV1 gp120 primary antibodies -
Description
Goat polyclonal to HIV1 gp120 -
Host species
Goat -
Tested applications
Suitable for: ELISA, WBmore details -
Species reactivity
Reacts with: Species independent -
Immunogen
Purified native gp120 from strain IIIB.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: 0.0268% PBS -
Concentration information loading... -
Purification notes
Purified by Sodium sulfate precipitation and ion-exchange chromatography.>95% pure. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab21179 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| WB | (1) |
1/1000. Predicted molecular weight: 120 kDa. Dilution optimised using Chromogenic detection
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| Notes |
|---|
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ELISA
Use at an assay dependent concentration. |
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WB
1/1000. Predicted molecular weight: 120 kDa. Dilution optimised using Chromogenic detection |
Target
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Relevance
HIV1 is equipped with the envelope gp160 glycoprotein for interaction with Langerhans cells (LCs) and dendritic cells (DCs), the members of the innate immune system, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of T helper 2 (Th2) cells, and is able to induce FcepsilonRI(+) hematopoietic cells to produce IL4, which inactivates the host adaptive immune response. -
Cellular localization
Envelope surface glycoprotein. -
Alternative names
- Glycoprotein 120 antibody
- gp120 antibody
- SU antibody
- Surface protein antibody
Datasheets and documents
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SDS download
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Datasheet download
References (23)
ab21179 has been referenced in 23 publications.
- Imamichi H et al. Defective HIV-1 proviruses produce viral proteins. Proc Natl Acad Sci U S A 117:3704-3710 (2020). PubMed: 32029589
- Liu Y et al. PSGL-1 inhibits HIV-1 infection by restricting actin dynamics and sequestering HIV envelope proteins. Cell Discov 6:53 (2020). PubMed: 32802403
- Zhang Y et al. MARCH8 inhibits viral infection by two different mechanisms. Elife 9:N/A (2020). PubMed: 32778221
- Giel-Moloney M et al. Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector. Sci Rep 9:20005 (2019). PubMed: 31882800
- Zhang Y et al. Membrane-associated RING-CH (MARCH) 1 and 2 are MARCH family members that inhibit HIV-1 infection. J Biol Chem 294:3397-3405 (2019). PubMed: 30630952