Key features and details
- Mouse monoclonal [10E9] to HIV1 gp41
- Suitable for: WB, Radioimmunoprecipitation, ELISA, ICC/IF
- Isotype: IgG1
Product nameAnti-HIV1 gp41 antibody [10E9]
See all HIV1 gp41 primary antibodies
DescriptionMouse monoclonal [10E9] to HIV1 gp41
SpecificityReacts with Human Immunodeficiency Virus Type 1(HIV 1) gp41 envelope transmembrane protein. Also exhibits strong reactivity with HIV 1 env gene precursor gp160 using Western blotting.
Tested applicationsSuitable for: WB, Radioimmunoprecipitation, ELISA, ICC/IFmore details
Species reactivityReacts with: Other species
Whole HIV viral lysate (B-3 strain). The epitope has not been mapped.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.2
Concentration information loading...
PurityProtein A purified
Purification notesPurified from serum-free culture supernatant.
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab9065 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC/IF: Use at a concentration of 1 - 10 mg/ml.
RipA: Use at an assay dependent dilution.
WB: Use at a concentration of 1 - 10 µg/ml.
Antibody dilutions should be prepared using buffers containing suitable protein in order to stabilize antibody activity.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Relevancegp41/120 is the major HIV protein associated with the HIV envelope. It functions as the viral antireceptor or attachment protein. gp41 (or TM) traverses the envelope, whereas gp120 is present on the outer surface and is noncovalently attached to gp41. The precursor of gp120/41 (gp160) is synthesized in the endoplasmic reticulum and is transported via the golgi body to the cell surface. Upon activation of the envelope glycoprotein (gp120/41) by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes.
- Env antibody
- Glycoprotein 41 antibody
- gp41 antibody
ab9065 has been referenced in 2 publications.
- Lebohang Manoto S et al. Exploring optical spectroscopic techniques and nanomaterials for virus detection. Saudi J Biol Sci N/A:N/A (2020). PubMed: 32868971
- Papsidero LD et al. Monoclonal antibody identifies a highly conserved and immunodominant epitope of the human immunodeficiency virus transmembrane protein. Hybridoma 7:117-28 (1988). PubMed: 2453451