Anti-HLA E antibody [MEM-E/08] (ab11821)
Key features and details
- Mouse monoclonal [MEM-E/08] to HLA E
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-HLA E antibody [MEM-E/08]
See all HLA E primary antibodies -
Description
Mouse monoclonal [MEM-E/08] to HLA E -
Host species
Mouse -
Specificity
The antibody recognized native surface-expressed HLA E, but not denaturated heavy chain of HLA E. The published results revealed that antibody is remarkably specific for HLA E, only with weak cross-reactivity with following classical MHC Class I molecules: HLA A24, B7, B27, B51, B54, C7. -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human HLA E.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.097% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Protein A purified -
Purification notes
Purified from hybridoma culture supernatant by protein A-affinity chromatography. -
Clonality
Monoclonal -
Clone number
MEM-E/08 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
Target
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Relevance
HLA E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. -
Cellular localization
Membrane; Single-pass type I membrane protein -
Database links
- Entrez Gene: 3133 Human
- Omim: 143010 Human
- SwissProt: P13747 Human
- Unigene: 650174 Human
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Alternative names
- HLA class I histocompatibility antigen E alpha chain antibody
- EA1.2 antibody
- EA2.1 antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (7)
ab11821 has been referenced in 7 publications.
- Wang F et al. S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3. Nat Immunol 17:514-522 (2016). WB, IP ; Mouse . PubMed: 27043414
- Boura JS et al. Evaluation of gene delivery strategies to efficiently overexpress functional HLA-G on human bone marrow stromal cells. Mol Ther Methods Clin Dev 2014:N/A (2014). Flow Cyt ; Human . PubMed: 25279386
- Soland MA et al. Modulation of Human Mesenchymal Stem Cell Immunogenicity through Forced Expression of Human Cytomegalovirus US Proteins. PLoS One 7:e36163 (2012). Flow Cyt ; Human . PubMed: 22666319
- Heidenreich S et al. Impact of the NK cell receptor LIR-1 (ILT-2/CD85j/LILRB1) on cytotoxicity against multiple myeloma. Clin Dev Immunol 2012:652130 (2012). Flow Cyt ; Human . PubMed: 22844324
- Kalkunte SS et al. Vascular endothelial growth factor C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface. J Immunol 182:4085-92 (2009). Flow Cyt ; Human . PubMed: 19299706
- Tennakoon DK et al. Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis. J Immunol 176:7119-29 (2006). Flow Cyt ; Human . PubMed: 16709875
- Brooks CR et al. The inhibitory receptor NKG2A determines lysis of vaccinia virus-infected autologous targets by NK cells. J Immunol 176:1141-7 (2006). Flow Cyt ; Human . PubMed: 16434388