Recombinant
RabMAb

Recombinant Anti-HMGA2 antibody [EPR18114] - BSA and Azide free (ab251468)

Submit a review Submit a question

Overview

  • Product name

    Anti-HMGA2 antibody [EPR18114] - BSA and Azide free
    See all HMGA2 primary antibodies

  • Description

    Rabbit monoclonal [EPR18114] to HMGA2 - BSA and Azide free

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Recombinant full length protein within Human HMGA2 aa 1 to the C-terminus. The exact sequence is proprietary.
    Database link: P52926

  • General notes

    Ab251468 is the carrier-free version of ab207301. This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.

     

    Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.

    Use our conjugation kits  for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

    ab251468 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.

    Maxpar® is a trademark of Fluidigm Canada Inc.

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

Applications

Our Abpromise guarantee covers the use of ab251468 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 12 kDa.
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
ICC/IF Use at an assay dependent concentration.

Target

  • Function

    Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2.

  • Involvement in disease

    Note=A chromosomal aberration involving HMGA2 is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with LPP is shown in lipomas. HMGA2 is also fused with a number of other genes in lipomas.
    Note=A chromosomal aberration involving HMGA2 is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with LPP is detected in pulmonary chondroid hamartomas.
    Note=A chromosomal aberration involving HMGA2 is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with LPP is also shown in one parosteal lipoma.
    Note=A chromosomal aberration involving HMGA2 is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with RAD51L1. Chromosomal rearrangements involving HMGA2 do not seem to be the principle pathobiological mechanism in uterine leiomyoma.

  • Sequence similarities

    Belongs to the HMGA family.
    Contains 3 A.T hook DNA-binding domains.

  • Developmental stage

    Expressed predominantly during embryogenesis.

  • Post-translational
    modifications

    Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity.

  • Cellular localization

    Nucleus.
  • Information by UniProt

  • Database links

    • Alternative names

      • HMGA 2 antibody
      • BABL antibody
      • High mobility group (nonhistone chromosomal) protein isoform I C antibody
      • High mobility group (nonhistone chromosomal) protein isoform IC antibody
      • High Mobility Group AT hook 2 antibody
      • High Mobility Group AT hook protein 2 antibody
      • High mobility group AT-hook protein 2 antibody
      • High mobility group protein HMGI C antibody
      • High mobility group protein HMGI-C antibody
      • High mobility group protein HMGIC antibody
      • High mobility group protein I, isoform C antibody
      • HMGA2 antibody
      • HMGA2_HUMAN antibody
      • HMGI C antibody
      • HMGIC antibody
      • LIPO antibody
      • Non histone chromosomal architectural protein HMGI C antibody
      • Non histone chromosomal architectural protein HMGIC antibody
      • Pygmy antibody
      • STQTL9 antibody
      see all

    References

    ab251468 has not yet been referenced specifically in any publications.

    Publishing research using ab251468? Please let us know so that we can cite the reference in this datasheet.

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    There are currently no Customer reviews or Questions for ab251468.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com