Validated using a knockout cell line

Anti-HMGB1 antibody [EPR3507] (ab79823)

Publishing research using ab79823? Please let us know so that we can cite the reference in this datasheet.

ab79823 has been referenced in 55 publications.

  • Morale MG  et al. HPV-transformed cells exhibit altered HMGB1-TLR4/MyD88-SARM1 signaling axis. Sci Rep 8:3476 (2018). WB . PubMed: 29472602
  • Wu DM  et al. S100A9 gene silencing inhibits the release of pro-inflammatory cytokines by blocking the IL-17 signalling pathway in mice with acute pancreatitis. J Cell Mol Med 22:2378-2389 (2018). WB ; Mouse . PubMed: 29441717
  • Zhang Y  et al. Pre-B cell leukemia transcription factor 3 induces inflammatory responses in human umbilical vein endothelial cells and murine sepsis via acting a competing endogenous RNA for high mobility group box 1 protein. Mol Med Rep 17:5805-5813 (2018). PubMed: 29484406
  • Liu YH  et al. The ATP-P2X7 Signaling Axis Is an Essential Sentinel for Intracellular Clostridium difficile Pathogen-Induced Inflammasome Activation. Front Cell Infect Microbiol 8:84 (2018). PubMed: 29616195
  • de Souza ABF  et al. High-Fat Diet Increases HMGB1 Expression and Promotes Lung Inflammation in Mice Subjected to Mechanical Ventilation. Oxid Med Cell Longev 2018:7457054 (2018). IHC-P ; Mouse . PubMed: 29619146
  • Xu Q  et al. High mobility group box 1 was associated with thrombosis in patients with atrial fibrillation. Medicine (Baltimore) 97:e0132 (2018). PubMed: 29595637
  • Zheng DW  et al. Optically-controlled bacterial metabolite for cancer therapy. Nat Commun 9:1680 (2018). PubMed: 29700283
  • de Carvalho GC  et al. Up-regulation of HMGB1 and TLR4 in skin lesions of lichen planus. Arch Dermatol Res N/A:N/A (2018). PubMed: 29728859
  • Xu Q  et al. Paeonol Reduces the Nucleocytoplasmic Transportation of HMGB1 by Upregulating HDAC3 in LPS-Induced RAW264.7 Cells. Inflammation N/A:N/A (2018). ICC ; Mouse . PubMed: 29736733
  • Xu X  et al. ERK1/2/mTOR/Stat3 pathway-mediated autophagy alleviates traumatic brain injury-induced acute lung injury. Biochim Biophys Acta 1864:1663-1674 (2018). WB . PubMed: 29466698
  • Luo Y  et al. Enzalutamide and CXCR7 inhibitor combination treatment suppresses cell growth and angiogenic signaling in castration-resistant prostate cancer models. Int J Cancer 142:2163-2174 (2018). IHC-P . PubMed: 29277895
  • Yan H  et al. HMGB1-RAGE signaling pathway in pPROM. Taiwan J Obstet Gynecol 57:211-216 (2018). WB, IHC-P ; Human . PubMed: 29673663
  • Hsiung S  et al. Hyperglycemia does not affect tissue repair responses in shear stress-induced atherosclerotic plaques in ApoE-/- mice. Sci Rep 8:7530 (2018). PubMed: 29760458
  • Deshmukh A  et al. Histological Characterization of the Irritative Zones in Focal Cortical Dysplasia Using a Preclinical Rat Model. Front Cell Neurosci 12:52 (2018). PubMed: 29867355
  • Ogundele OM  et al. Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIa expression in neural changes associated with a prolonged exposure therapy. Neuroscience 353:147-165 (2017). IHC-Fr ; Rat . PubMed: 28438613
  • Romero M  et al. Intrinsic repair protects cells from pore-forming toxins by microvesicle shedding. Cell Death Differ N/A:N/A (2017). PubMed: 28186501
  • Huang J  et al. HMGB1 Mediates Autophagy Dysfunction via Perturbing Beclin1-Vps34 Complex in Dopaminergic Cell Model. Front Mol Neurosci 10:13 (2017). WB ; Human . PubMed: 28197072
  • Zhao G  et al. Down-regulation of nuclear HMGB1 reduces ischemia-induced HMGB1 translocation and release and protects against liver ischemia-reperfusion injury. Sci Rep 7:46272 (2017). PubMed: 28382970
  • Wu J  et al. Electroacupuncture improves acute bowel injury recovery in rat models. Exp Ther Med 14:4655-4662 (2017). PubMed: 29201164
  • Oliveira ERA  et al. Dengue fatal cases present virus-specific HMGB1 response in peripheral organs. Sci Rep 7:16011 (2017). PubMed: 29167501
  • Xiahou Z  et al. NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury. Nat Commun 8:950 (2017). PubMed: 29038465
  • Rao Z  et al. 1,25-Dihydroxyvitamin D Inhibits LPS-Induced High-Mobility Group Box 1 (HMGB1) SecretionviaTargeting the NF-E2-Related Factor 2-Hemeoxygenase-1-HMGB1 Pathway in Macrophages. Front Immunol 8:1308 (2017). PubMed: 29085368
  • Fabre NT  et al. Hormetic modulation of hepatic insulin sensitivity by advanced glycation end products. Mol Cell Endocrinol 447:116-124 (2017). PubMed: 28238722
  • Wang Y  et al. Activation of the HMGB1-TLR4-NF-?B pathway may occur in patients with atopic eczema. Mol Med Rep 16:2714-2720 (2017). PubMed: 28713916
  • Ahn MY  et al. Subcritical water-hydrolyzed fish collagen ameliorates survival of endotoxemic mice by inhibiting HMGB1 release in a HO-1-dependent manner. Biomed Pharmacother 93:923-930 (2017). PubMed: 28715873
  • Li LC  et al. Astragaloside IV Improves Bleomycin-Induced Pulmonary Fibrosis in Rats by Attenuating Extracellular Matrix Deposition. Front Pharmacol 8:513 (2017). PubMed: 28848434
  • Tanaka M  et al. Immunogenic cell death due to a new photodynamic therapy (PDT) with glycoconjugated chlorin (G-chlorin). Oncotarget 7:47242-47251 (2016). IHC . PubMed: 27363018
  • Bai L  et al. Inhibition of the translocation and extracellular release of high-mobility group box 1 alleviates liver damage in fibrotic mice in response to D-galactosamine/lipopolysaccharide challenge. Mol Med Rep 13:3835-41 (2016). IF, IHC . PubMed: 27035642
  • Carniglia L  et al. [Nle4, D-Phe7]-a-MSH Inhibits Toll-Like Receptor (TLR)2- and TLR4-Induced Microglial Activation and Promotes a M2-Like Phenotype. PLoS One 11:e0158564 (2016). ICC . PubMed: 27359332
  • Colangelo T  et al. The miR-27a-calreticulin axis affects drug-induced immunogenic cell death in human colorectal cancer cells. Cell Death Dis 7:e2108 (2016). WB . PubMed: 26913599
  • Wang J  et al. Cerebral ischemic post-conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model. Mol Med Rep 14:4162-4172 (2016). WB, IP, IF ; Rat . PubMed: 27666823
  • Yu C  et al. Expression pattern of HMGB1 and its association with autophagy in acute necrotizing pancreatitis. Mol Med Rep 14:5507-5513 (2016). WB, IHC (PFA fixed) ; Rat . PubMed: 27878276
  • Li G  et al. TLR4-mediated NF-?B signaling pathway mediates HMGB1-induced pancreatic injury in mice with severe acute pancreatitis. Int J Mol Med 37:99-107 (2016). WB ; Mouse . PubMed: 26719855
  • Berger EA  et al. ß-Adrenergic receptor agonist, compound 49b, inhibits TLR4 signaling pathway in diabetic retina. Immunol Cell Biol 94:656-61 (2016). WB ; Rat . PubMed: 26888251
  • Li X  et al. Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-?B signaling pathways. Toxicol Lett 261:1-12 (2016). PubMed: 27601294
  • Fonken LK  et al. The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming. J Neurosci 36:7946-56 (2016). WB ; Rat . PubMed: 27466339
  • Terrando N  et al. Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats. Front Immunol 7:441 (2016). PubMed: 27822212
  • Kawano M  et al. Dendritic cells combined with doxorubicin induces immunogenic cell death and exhibits antitumor effects for osteosarcoma. Oncol Lett 11:2169-2175 (2016). PubMed: 26998143
  • Yuan D  et al. Blue light reduces organ injury from ischemia and reperfusion. Proc Natl Acad Sci U S A 113:5239-44 (2016). PubMed: 27114521
  • Rizvi F  et al. Suppression in PHLPP2 induction by morin promotes Nrf2-regulated cellular defenses against oxidative injury to primary rat hepatocytes. Redox Biol 6:587-98 (2015). PubMed: 26513344
  • Zhang J  et al. Overexpression of microRNA-141 relieves chronic constriction injury-induced neuropathic pain via targeting high-mobility group box 1. Int J Mol Med 36:1433-9 (2015). PubMed: 26398163
  • Hoste E  et al. Innate sensing of microbial products promotes wound-induced skin cancer. Nat Commun 6:5932 (2015). IF . PubMed: 25575023
  • Yao HC  et al. Postconditioning with simvastatin decreases myocardial injury in rats following acute myocardial ischemia. Exp Ther Med 9:1166-1170 (2015). WB . PubMed: 25780404
  • Kim H  et al. Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria. Infect Immun 82:371-9 (2014). PubMed: 24191300
  • Liu Y  et al. A novel androstenedione derivative induces ROS-mediated autophagy and attenuates drug resistance in osteosarcoma by inhibiting macrophage migration inhibitory factor (MIF). Cell Death Dis 5:e1361 (2014). WB ; Human . PubMed: 25101674
  • Weng H  et al. Effects of high mobility group protein box 1 and toll like receptor 4 pathway on warts caused by human papillomavirus. Mol Med Rep 10:1765-71 (2014). IHC-P ; Human . PubMed: 25118798
  • Sun S  et al. Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways. PLoS One 8:e59989 (2013). WB ; Human . PubMed: 23527291
  • Wolf M  et al. Regulation of high mobility group box protein 1 expression following mechanical loading by orthodontic forces in vitro and in vivo. Eur J Orthod N/A:N/A (2013). PubMed: 23720448
  • Weng H  et al. Expression and significance of HMGB1, TLR4 and NF-?B p65 in human epidermal tumors. BMC Cancer 13:311 (2013). IHC-P ; Human . PubMed: 23803172
  • Wolf M  et al. High-mobility group box protein-1 released by human-periodontal ligament cells cells modulates macrophage migration and activity in vitro. Innate Immun N/A:N/A (2013). ICC/IF ; Human . PubMed: 24107514
  • Belgrano FS  et al. Role of the acidic tail of high mobility group protein B1 (HMGB1) in protein stability and DNA bending. PLoS One 8:e79572 (2013). WB ; Human . PubMed: 24255708
  • Wagner M  et al. Loss of adipocyte specification and necrosis augment tumor-associated inflammation. Adipocyte 2:176-83 (2013). IHC-P ; Mouse . PubMed: 23991365
  • Vicentino AR  et al. Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a Novel Anti-Inflammatory Drug Candidate. PLoS One 7:e39104 (2012). ICC/IF ; Mouse . PubMed: 22723938
  • Hayakawa K  et al. Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery. Proc Natl Acad Sci U S A 109:7505-10 (2012). WB ; Rat . PubMed: 22529378
  • Chen KB  et al. High-mobility group box-1 and its receptors contribute to proinflammatory response in the acute phase of spinal cord injury in rats. Spine (Phila Pa 1976) 36:2122-9 (2011). Rat . PubMed: 21343866


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