Anti-HNF-4-alpha antibody [K9218] - ChIP Grade (ab41898)

Mouse monoclonal HNF-4-alpha antibody [K9218]. Validated in WB, IP, ELISA, IHC, Flow Cyt, ChIP, ICC/IF and tested in Mouse, Rat, Cow, Human. Cited in 40 publication(s).

Publishing research using ab41898? Please let us know so that we can cite the reference in this datasheet.

ab41898 has been referenced in 42 publications.

  • Ma Z  et al. Autophagy promotes hepatic differentiation of hepatic progenitor cells by regulating the Wnt/ß-catenin signaling pathway. J Mol Histol 50:75-90 (2019). PubMed: 30604254
  • Qin Y  et al. An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression. Genome Biol 19:7 (2018). PubMed: 29361968
  • Lu Y  et al. Hepatic leukocyte immunoglobulin-like receptor B4 (LILRB4) attenuates nonalcoholic fatty liver disease via SHP1-TRAF6 pathway. Hepatology 67:1303-1319 (2018). IHC ; Mouse . PubMed: 29091299
  • Guzman-Lepe J  et al. Liver-enriched transcription factor expression relates to chronic hepatic failure in humans. Hepatol Commun 2:582-594 (2018). PubMed: 29761173
  • Reebye V  et al. Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer. Oncogene 37:3216-3228 (2018). PubMed: 29511346
  • Jiang Y  et al. H19 Is Expressed in Hybrid Hepatocyte Nuclear Factor 4a+ Periportal Hepatocytes but Not Cytokeratin 19+ Cholangiocytes in Cholestatic Livers. Hepatol Commun 2:1356-1368 (2018). PubMed: 30411082
  • Zhang Y  et al. Therapeutic effect of hepatocyte growth factor-overexpressing bone marrow-derived mesenchymal stem cells on CCl4-induced hepatocirrhosis. Cell Death Dis 9:1186 (2018). PubMed: 30538216
  • Tricot T  et al. Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals. PLoS One 13:e0209097 (2018). PubMed: 30566505
  • Kaylan KB  et al. Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling. Elife 7:N/A (2018). PubMed: 30589410
  • Varghese DS  et al. Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro. Stem Cells Int 2017:2451927 (2017). PubMed: 29147115
  • Pistoni M  et al. Dynamic regulation of EZH2 from HPSc to hepatocyte-like cell fate. PLoS One 12:e0186884 (2017). PubMed: 29091973
  • Cai SH  et al. Increased expression of hepatocyte nuclear factor 4 alpha transcribed by promoter 2 indicates a poor prognosis in hepatocellular carcinoma. Therap Adv Gastroenterol 10:761-771 (2017). PubMed: 29051787
  • Vethe H  et al. Probing the missing mature ß-cell proteomic landscape in differentiating patient iPSC-derived cells. Sci Rep 7:4780 (2017). PubMed: 28684784
  • Veto B  et al. The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2. PLoS One 12:e0172020 (2017). ChIP ; Human . PubMed: 28196117
  • Stryjewska A  et al. Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells. Stem Cells 35:611-625 (2017). PubMed: 27739137
  • Yao J  et al. Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. J Cell Biol 216:3369-3385 (2017). PubMed: 28838957
  • Kastenhuber ER  et al. DNAJB1-PRKACA fusion kinase interacts with ß-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma. Proc Natl Acad Sci U S A 114:13076-13084 (2017). PubMed: 29162699
  • Moreno M  et al. 3,5,3'-Triiodo-L-Thyronine- and 3,5-Diiodo-L-Thyronine- Affected Metabolic Pathways in Liver of LDL Receptor Deficient Mice. Front Physiol 7:545 (2016). WB ; Mouse . PubMed: 27909409
  • Wang PX  et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun 7:10592 (2016). IF . PubMed: 26882989
  • Moshfegh C  et al. A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways. Sci Rep 6:25104 (2016). IF . PubMed: 27157261
  • Chang H  et al. Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition. Nucleic Acids Res 44:2514-27 (2016). ChIP . PubMed: 26926107
  • Yi J  et al. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Hepatology 64:1757-1772 (2016). PubMed: 27531557
  • Liao J  et al. Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Nat Genet 47:469-78 (2015). ICC/IF ; Human . PubMed: 25822089
  • Conigliaro A  et al. CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA. Mol Cancer 14:155 (2015). ICC . PubMed: 26272696
  • Maples JM  et al. Differential epigenetic and transcriptional response of the skeletal muscle carnitine palmitoyltransferase 1B (CPT1B) gene to lipid exposure with obesity. Am J Physiol Endocrinol Metab 309:E345-56 (2015). PubMed: 26058865
  • Pihlajamaa P  et al. Tissue-specific pioneer factors associate with androgen receptor cistromes and transcription programs. EMBO J 33:312-26 (2014). PubMed: 24451200
  • Algamas-Dimantov A  et al. Prevention of diabetes-promoted colorectal cancer by (n-3) polyunsaturated fatty acids and (n-3) PUFA mimetic. Oncotarget 5:9851-63 (2014). IHC . PubMed: 25375205
  • Simeone P  et al. A unique four-hub protein cluster associates to glioblastoma progression. PLoS One 9:e103030 (2014). IHC-P ; Human . PubMed: 25050814
  • Saha SK  et al. Mutant IDH inhibits HNF-4a to block hepatocyte differentiation and promote biliary cancer. Nature 513:110-4 (2014). PubMed: 25043045
  • Chahar S  et al. Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4a during colitis. Mol Cell Biol 34:3291-304 (2014). ChIP ; Mouse . PubMed: 24980432
  • Prestin K  et al. Transcriptional regulation of urate transportosome member SLC2A9 by nuclear receptor HNF4a. Am J Physiol Renal Physiol 307:F1041-51 (2014). PubMed: 25209865
  • Ouyang H  et al. Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. PLoS One 8:e62192 (2013). ChIP . PubMed: 23626788
  • Choudhary RK  et al. Comparison of the transcriptomes of long-term label retaining-cells and control cells microdissected from mammary epithelium: an initial study to characterize potential stem/progenitor cells. Front Oncol 3:21 (2013). IHC-P ; Cow . PubMed: 23423481
  • Pennarossa G  et al. Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells. Proc Natl Acad Sci U S A 110:8948-53 (2013). Human . PubMed: 23696663
  • Conigliaro A  et al. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. Cell Death Differ 20:1116-23 (2013). PubMed: 23686136
  • Tümer E  et al. Enterocyte-specific regulation of the apical nutrient transporter SLC6A19 (B(0)AT1) by transcriptional and epigenetic networks. J Biol Chem 288:33813-23 (2013). ChIP . PubMed: 24121511
  • Gürlevik E  et al. Adjuvant gemcitabine therapy improves survival in a locally induced, R0-resectable model of metastatic intrahepatic cholangiocarcinoma. Hepatology 58:1031-41 (2013). PubMed: 23686746
  • Algamas-Dimantov A  et al. Amelioration of diabesity-induced colorectal ontogenesis by omega-3 fatty acids in mice. J Lipid Res 53:1056-70 (2012). IHC-P ; Mouse . PubMed: 22357704
  • de Boussac H  et al. The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes. J Biol Chem 285:22800-8 (2010). ChIP ; Human . PubMed: 20463007
  • Haase A  et al. Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell 5:434-41 (2009). ICC/IF ; Human . PubMed: 19796623
  • Schwartz B  et al. Inhibition of colorectal cancer by targeting hepatocyte nuclear factor-4alpha. Int J Cancer 124:1081-9 (2009). PubMed: 19048623
  • Quasdorff M  et al. A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation. Cell Microbiol 10:1478-90 (2008). IHC-P ; Human . PubMed: 18346225

For licensing inquiries, please contact

Sign up