Anti-HNF-4-alpha antibody [K9218] - ChIP Grade (ab41898)

Mouse monoclonal HNF-4-alpha antibody [K9218]. Validated in WB, IP, ELISA, IHC, Flow Cyt, ChIP, ICC/IF and tested in Mouse, Rat, Cow, Human. Cited in 40 publication(s).

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ab41898 has been referenced in 42 publications.

  • Ma Z  et al. Autophagy promotes hepatic differentiation of hepatic progenitor cells by regulating the Wnt/ß-catenin signaling pathway. J Mol Histol 50:75-90 (2019). PubMed: 30604254
  • Qin Y  et al. An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression. Genome Biol 19:7 (2018). PubMed: 29361968
  • Lu Y  et al. Hepatic leukocyte immunoglobulin-like receptor B4 (LILRB4) attenuates nonalcoholic fatty liver disease via SHP1-TRAF6 pathway. Hepatology 67:1303-1319 (2018). IHC ; Mouse . PubMed: 29091299
  • Guzman-Lepe J  et al. Liver-enriched transcription factor expression relates to chronic hepatic failure in humans. Hepatol Commun 2:582-594 (2018). PubMed: 29761173
  • Reebye V  et al. Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer. Oncogene 37:3216-3228 (2018). PubMed: 29511346
  • Jiang Y  et al. H19 Is Expressed in Hybrid Hepatocyte Nuclear Factor 4a+ Periportal Hepatocytes but Not Cytokeratin 19+ Cholangiocytes in Cholestatic Livers. Hepatol Commun 2:1356-1368 (2018). PubMed: 30411082
  • Zhang Y  et al. Therapeutic effect of hepatocyte growth factor-overexpressing bone marrow-derived mesenchymal stem cells on CCl4-induced hepatocirrhosis. Cell Death Dis 9:1186 (2018). PubMed: 30538216
  • Tricot T  et al. Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals. PLoS One 13:e0209097 (2018). PubMed: 30566505
  • Kaylan KB  et al. Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling. Elife 7:N/A (2018). PubMed: 30589410
  • Varghese DS  et al. Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro. Stem Cells Int 2017:2451927 (2017). PubMed: 29147115
  • Pistoni M  et al. Dynamic regulation of EZH2 from HPSc to hepatocyte-like cell fate. PLoS One 12:e0186884 (2017). PubMed: 29091973
  • Cai SH  et al. Increased expression of hepatocyte nuclear factor 4 alpha transcribed by promoter 2 indicates a poor prognosis in hepatocellular carcinoma. Therap Adv Gastroenterol 10:761-771 (2017). PubMed: 29051787
  • Vethe H  et al. Probing the missing mature ß-cell proteomic landscape in differentiating patient iPSC-derived cells. Sci Rep 7:4780 (2017). PubMed: 28684784
  • Veto B  et al. The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2. PLoS One 12:e0172020 (2017). ChIP ; Human . PubMed: 28196117
  • Stryjewska A  et al. Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells. Stem Cells 35:611-625 (2017). PubMed: 27739137
  • Yao J  et al. Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. J Cell Biol 216:3369-3385 (2017). PubMed: 28838957
  • Kastenhuber ER  et al. DNAJB1-PRKACA fusion kinase interacts with ß-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma. Proc Natl Acad Sci U S A 114:13076-13084 (2017). PubMed: 29162699
  • Moreno M  et al. 3,5,3'-Triiodo-L-Thyronine- and 3,5-Diiodo-L-Thyronine- Affected Metabolic Pathways in Liver of LDL Receptor Deficient Mice. Front Physiol 7:545 (2016). WB ; Mouse . PubMed: 27909409
  • Wang PX  et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun 7:10592 (2016). IF . PubMed: 26882989
  • Moshfegh C  et al. A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways. Sci Rep 6:25104 (2016). IF . PubMed: 27157261
  • Chang H  et al. Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition. Nucleic Acids Res 44:2514-27 (2016). ChIP . PubMed: 26926107
  • Yi J  et al. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Hepatology 64:1757-1772 (2016). PubMed: 27531557
  • Liao J  et al. Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Nat Genet 47:469-78 (2015). ICC/IF ; Human . PubMed: 25822089
  • Conigliaro A  et al. CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA. Mol Cancer 14:155 (2015). ICC . PubMed: 26272696
  • Maples JM  et al. Differential epigenetic and transcriptional response of the skeletal muscle carnitine palmitoyltransferase 1B (CPT1B) gene to lipid exposure with obesity. Am J Physiol Endocrinol Metab 309:E345-56 (2015). PubMed: 26058865
  • Pihlajamaa P  et al. Tissue-specific pioneer factors associate with androgen receptor cistromes and transcription programs. EMBO J 33:312-26 (2014). PubMed: 24451200
  • Algamas-Dimantov A  et al. Prevention of diabetes-promoted colorectal cancer by (n-3) polyunsaturated fatty acids and (n-3) PUFA mimetic. Oncotarget 5:9851-63 (2014). IHC . PubMed: 25375205
  • Simeone P  et al. A unique four-hub protein cluster associates to glioblastoma progression. PLoS One 9:e103030 (2014). IHC-P ; Human . PubMed: 25050814
  • Saha SK  et al. Mutant IDH inhibits HNF-4a to block hepatocyte differentiation and promote biliary cancer. Nature 513:110-4 (2014). PubMed: 25043045
  • Chahar S  et al. Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4a during colitis. Mol Cell Biol 34:3291-304 (2014). ChIP ; Mouse . PubMed: 24980432
  • Prestin K  et al. Transcriptional regulation of urate transportosome member SLC2A9 by nuclear receptor HNF4a. Am J Physiol Renal Physiol 307:F1041-51 (2014). PubMed: 25209865
  • Ouyang H  et al. Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. PLoS One 8:e62192 (2013). ChIP . PubMed: 23626788
  • Choudhary RK  et al. Comparison of the transcriptomes of long-term label retaining-cells and control cells microdissected from mammary epithelium: an initial study to characterize potential stem/progenitor cells. Front Oncol 3:21 (2013). IHC-P ; Cow . PubMed: 23423481
  • Pennarossa G  et al. Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells. Proc Natl Acad Sci U S A 110:8948-53 (2013). Human . PubMed: 23696663
  • Conigliaro A  et al. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. Cell Death Differ 20:1116-23 (2013). PubMed: 23686136
  • Tümer E  et al. Enterocyte-specific regulation of the apical nutrient transporter SLC6A19 (B(0)AT1) by transcriptional and epigenetic networks. J Biol Chem 288:33813-23 (2013). ChIP . PubMed: 24121511
  • Gürlevik E  et al. Adjuvant gemcitabine therapy improves survival in a locally induced, R0-resectable model of metastatic intrahepatic cholangiocarcinoma. Hepatology 58:1031-41 (2013). PubMed: 23686746
  • Algamas-Dimantov A  et al. Amelioration of diabesity-induced colorectal ontogenesis by omega-3 fatty acids in mice. J Lipid Res 53:1056-70 (2012). IHC-P ; Mouse . PubMed: 22357704
  • de Boussac H  et al. The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes. J Biol Chem 285:22800-8 (2010). ChIP ; Human . PubMed: 20463007
  • Haase A  et al. Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell 5:434-41 (2009). ICC/IF ; Human . PubMed: 19796623
  • Schwartz B  et al. Inhibition of colorectal cancer by targeting hepatocyte nuclear factor-4alpha. Int J Cancer 124:1081-9 (2009). PubMed: 19048623
  • Quasdorff M  et al. A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation. Cell Microbiol 10:1478-90 (2008). IHC-P ; Human . PubMed: 18346225

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