Overview

  • Product name

    HNMPA-(AM)3, Insulin receptor tyrosine kinase inhibitor
  • Description

    Insulin receptor tyrosine kinase inhibitor
  • Biological description

    Insulin receptor tyrosine kinase inhibitor (IC50 = 100 μM). Inhibits serine and tyrosine autophosphorylation by the human insulin receptor. Cell-permeable analog of HNMPA (cell impermeable analog available ab141566).
  • Purity

    > 98%
  • General notes

    Product's appearance is colorless oil

  • CAS Number

    120944-03-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Record RD  et al. Phosphatidylinositol 3-kinase activation is required for insulin-stimulated sodium transport in A6 cells. Am J Physiol 274:E611-7 (1998). Read more (PubMed: 9575821) »
  • Leibiger IB  et al. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. Mol Cell 1:933-8 (1998). Read more (PubMed: 9660977) »
  • Baltensperger K  et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A 89:7885-9 (1992). Read more (PubMed: 1381504) »
  • Saperstein R  et al. Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells. Biochemistry 28:5694-701 (1989). Read more (PubMed: 2550060) »
See 1 Publication for this product

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