Overview

  • Product name
    Anti-HOMER2 antibody - C-terminal
  • Description
    Rabbit polyclonal to HOMER2 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Horse, Guinea pig, Cow, Cat, Dog, Human, Pig
  • Immunogen

    Synthetic peptide within Mouse HOMER2 aa 217-266 (C terminal). The exact sequence is proprietary.
    Sequence:

    ICRDENDRLRSKIEELEEQCSEINREKEKNTQLKRRIEELESEVRDKEME


    Database link: Q9QWW1

  • Positive control
    • Mouse testis lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab177383 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 41 kDa.

Target

  • Function
    Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
  • Sequence similarities
    Belongs to the Homer family.
    Contains 1 WH1 domain.
  • Domain
    The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.
  • Cellular localization
    Cytoplasm. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACPD antibody
    • CPD antibody
    • Cupidin antibody
    • HOME2_HUMAN antibody
    • HOMER 2 antibody
    • HOMER 2A antibody
    • HOMER 2B antibody
    • Homer homolog 2 (Drosophila) antibody
    • Homer homolog 3 antibody
    • Homer neuronal immediate early gene 2 antibody
    • Homer protein homolog 2 antibody
    • Homer-2 antibody
    • Homer2 antibody
    • HOMER2A antibody
    • HOMER2B antibody
    • Vesl 2 antibody
    • Vesl2 antibody
    see all

Images

  • Anti-HOMER2 antibody - C-terminal (ab177383) at 1 µg/ml + Mouse testis lysate at 10 µg

    Predicted band size: 41 kDa

References

ab177383 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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