Overview

  • Product name

    Homoharringtonine, Protein synthesis inhibitor
  • Description

    Protein synthesis inhibitor. Selective 60S ribosome inhibitor.
  • Biological description

    Protein synthesis inhibitor. Selective 60S ribosome inhibitor. Prevents substrate binding to the acceptor site on the 60S ribosome subunit. Inhibits elongation phase of translation. Shows antitumor effects in vivo.
  • Purity

    > 97%
  • CAS Number

    26833-87-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methy-lpentyl)butanedioate
  • Molecular weight

    545.62
  • Molecular formula

    C29H39NO9
  • PubChem identifier

    56841046
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(CCCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jin Y  et al. The antitumor activity of homoharringtonine against human mast cells harboring the KIT D816V mutation. Mol Cancer Ther 9:211-23 (2010). Read more (PubMed: 20053766) »
  • Cai Z  et al. Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation. Leukemia 15:567-74 (2001). Read more (PubMed: 11368358) »
  • Tujebajeva RM  et al. Selective inhibition of the polypeptide chain elongation in eukaryotic cells. Biochim Biophys Acta 1129:177-82 (1992). Read more (PubMed: 1730056) »
  • Fresno M  et al. Inhibition of translation in eukaryotic systems by harringtonine. Eur J Biochem 72:323-30 (1977). Read more (PubMed: 319998) »

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