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Honokiol, anti-inflammatory and chemotherapeutic agent (ab120647)

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Chemical Structure - Honokiol, anti-inflammatory and chemotherapeutic agent (ab120647)
  • Functional Studies - Honokiol, anti-inflammatory and chemotherapeutic agent (ab120647)
  • Functional Studies - Honokiol, anti-inflammatory and chemotherapeutic agent (ab120647)

Key features and details

  • Anti-inflammatory and chemotherapeutic agent
  • CAS Number: 35354-74-6
  • Purity: > 98%
  • Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Honokiol, anti-inflammatory and chemotherapeutic agent
  • Description

    Anti-inflammatory and chemotherapeutic agent
  • Biological description

    Potent scavenger of reactive oxygen species with antiangiogenic, antitumor and anti-inflammatory properties. Mechanisms of action include inhibition of ras signalling and activation of the mitochondrial transistion pore via cyclophilin D induction. Inhibits NF-κB signaling, upstream of VEGF. Blood-brain barrier permeable.

  • Purity

    > 98%
  • CAS Number

    35354-74-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5,3'-Diallyl-2,4'-dihydroxybiphenyl
  • Molecular weight

    266.34
  • Molecular formula

    C18H18O2
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

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Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120647 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - Honokiol, anti-inflammatory and chemotherapeutic agent (ab120647)
    Chemical Structure - Honokiol, anti-inflammatory and chemotherapeutic agent (ab120647)
    2D chemical structure image of ab120647, Honokiol, anti-inflammatory and chemotherapeutic agent
  • Functional Studies - Honokiol, anti-inflammatory and chemotherapeutic agent (ab120647)
    Functional Studies - Honokiol, anti-inflammatory and chemotherapeutic agent (ab120647)

    MCF7 cells were incubated at 37°C for 6h with vehicle control (0 µM) and different concentrations of honokiol(ab120647). Increased expression of acetyl coenzyme A carboxylase (phospho S79)(ab31931) in MCF7 cells correlates with an increase in honokiol concentration, as described in literature.

    Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 µg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab31931 at 1 µg/ml and ab8227 at 1 µg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.

  • Functional Studies - Honokiol, anti-inflammatory and chemotherapeutic agent (ab120647)
    Functional Studies - Honokiol, anti-inflammatory and chemotherapeutic agent (ab120647)

    MCF7 cells were incubated at 37°C for 6h with vehicle control (0 µM) and different concentrations of honokiol(ab120647). Increased expression of AMPKα 1 + AMPKα 2 (phospho T172) (ab23875) in MCF7 cells correlates with an increase in honokiol concentration, as described in literature.

    Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 µg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab23875 at 1/1000 dilution and ab8227 at 1 µg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (0)

Publishing research using ab120647? Please let us know so that we can cite the reference in this datasheet.

ab120647 has not yet been referenced specifically in any publications.

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