Overview

  • Product name

    HPI-1, hedgehog signaling inhibitor
  • Description

    Potent hedgehog signaling inhibitor
  • Biological description

    Potent hedgehog signaling inhibitor (IC50 values are 1.5 (Shh), 1.5 (SAG), 4 (Gli2) and 6 μM (Gli1)). Antitumor agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    599150-20-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate
  • Molecular weight

    463.52
  • Molecular formula

    C27H29NO6.xH2O
  • PubChem identifier

    2926768
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Xu Y  et al. Polymeric nanoparticle-encapsulated hedgehog pathway inhibitor HPI-1 (NanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma. Clin Cancer Res 18:1291-302 (2012). Read more (PubMed: 21868763) »
  • Heretsch P  et al. Modulators of the hedgehog signaling pathway. Bioorg Med Chem 18:6613-24 (2010). Read more (PubMed: 20708941) »
  • Hyman JM  et al. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci U S A 106:14132-7 (2009). Read more (PubMed: 19666565) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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