Key features and details
- Mouse monoclonal [C1P5] to HPV16 E6 + HPV18 E6, prediluted
- Suitable for: IHC-Fr, IHC-P
- Reacts with: Human papillomavirus
- Isotype: IgG1
Product nameAnti-HPV16 E6 + HPV18 E6 antibody [C1P5], prediluted
See all HPV16 E6 + HPV18 E6 primary antibodies
DescriptionMouse monoclonal [C1P5] to HPV16 E6 + HPV18 E6, prediluted
SpecificityThis antibody is specific for Human Papilloma virus Early Antigen E6, HPV 16 and 18
Tested applicationsSuitable for: IHC-Fr, IHC-Pmore details
Species reactivityReacts with: Human papillomavirus
Recombinant full length protein corresponding to Human papillomavirus HPV16 E6 + HPV18 E6.
Database link: P06463
- IHC-P: HPV-positive vulva carcinoma.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.30
Preservative: 0.09% Sodium azide
Stabilising phosphate buffer, pH 7.3
Concentration information loading...
Our Abpromise guarantee covers the use of ab51931 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-Fr||Use at an assay dependent concentration.|
|IHC-P||Use at an assay dependent concentration.|
RelevanceHuman Papilloma virus (HPV) is responsible for the development of type and tissue specific papilloma in the oral cavity and in the larynx. In the skin papilloma virus can cause different types of warts and in the ano-genital region it is associated with condyloma or carcinoma. HPV types 1,6 and 11 usually are associated with benign transformations of the tissues, while e.g. HPV types 16, 18 and 31 seem to be responsible for the development of some carcinoma like cervical carcinoma. The role of HPV in non-melanoic tumours of the skin is under discussion. Protein E6 is a Transcriptional transactivator, binding double stranded DNA. It has transforming activity inactivating, with E6-AP ubiquitin-protein ligase, the human TP53/p53 tumor suppressor protein by targeting it for degradation.
- E6 antibody
- Human Papilloma Virus antibody
- Human papillomavirus type 16 E6 antibody
ab51931 has been referenced in 2 publications.
- Meng Y et al. PD-L1 Expression Correlates With Tumor Infiltrating Lymphocytes And Response To Neoadjuvant Chemotherapy In Cervical Cancer. J Cancer 9:2938-2945 (2018). PubMed: 30123362
- Yang J et al. Inhibition of antiviral drug cidofovir on proliferation of human papillomavirus-infected cervical cancer cells. Exp Ther Med 12:2965-2973 (2016). WB ; Human papillomavirus . PubMed: 27882102