Overview

  • Product name

    Anti-HPV16 E6 + HPV18 E6 antibody [C1P5], prediluted
    See all HPV16 E6 + HPV18 E6 primary antibodies
  • Description

    Mouse monoclonal [C1P5] to HPV16 E6 + HPV18 E6, prediluted
  • Host species

    Mouse
  • Specificity

    This antibody is specific for Human Papilloma virus Early Antigen E6, HPV 16 and 18
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human papillomavirus
  • Immunogen

    Recombinant full length protein corresponding to HPV16 E6 + HPV18 E6.

  • Positive control

    • HPV-positive vulva carcinoma

Properties

Applications

Our Abpromise guarantee covers the use of ab51931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.

Target

  • Relevance

    Human Papilloma virus (HPV) is responsible for the development of type and tissue specific papilloma in the oral cavity and in the larynx. In the skin papilloma virus can cause different types of warts and in the ano-genital region it is associated with condyloma or carcinoma. HPV types 1,6 and 11 usually are associated with benign transformations of the tissues, while e.g. HPV types 16, 18 and 31 seem to be responsible for the development of some carcinoma like cervical carcinoma. The role of HPV in non-melanoic tumours of the skin is under discussion. Protein E6 is a Transcriptional transactivator, binding double stranded DNA. It has transforming activity inactivating, with E6-AP ubiquitin-protein ligase, the human TP53/p53 tumor suppressor protein by targeting it for degradation.
  • Database links

    • Alternative names

      • E6 antibody
      • Human Papilloma Virus antibody
      • Human papillomavirus type 16 E6 antibody
      • Human papillomavirus type 18 E6 antibody
      • Protein E6 antibody
      see all

    Images

    • ab51931 staining HPV 16/18 in combinnation with biotinylated anti-mouse IgG, Streptavidin-AP and Fast Red staining. Retrieval method was antigen unmasking with citrate buffer pH 6 (2 x 5 min microwave oven 600 Watt). ab51931 was used undiluted, secondary AB 1:200, Streptavidin:AP 1:100.

    References

    This product has been referenced in:

    • Meng Y  et al. PD-L1 Expression Correlates With Tumor Infiltrating Lymphocytes And Response To Neoadjuvant Chemotherapy In Cervical Cancer. J Cancer 9:2938-2945 (2018). Read more (PubMed: 30123362) »
    • Yang J  et al. Inhibition of antiviral drug cidofovir on proliferation of human papillomavirus-infected cervical cancer cells. Exp Ther Med 12:2965-2973 (2016). WB ; Human papillomavirus . Read more (PubMed: 27882102) »
    See all 2 Publications for this product

    Customer reviews and Q&As

    Question
    Answer

    Thank you for contacting us.

    Both current lotswere identical in preparation and the final IgG concentration isapprox. 4.5 µg/ml.

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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