Overview

  • Product name

    Anti-HPV18 E6 antibody [BF7]
  • Description

    Mouse monoclonal [BF7] to HPV18 E6
  • Host species

    Mouse
  • Tested applications

    Suitable for: WB, RIA, ELISAmore details
  • Species reactivity

    Reacts with: Other species
  • Immunogen

    Gel-purified HPV-18 E6-beta-galactosidase fusion protein

Properties

Applications

Our Abpromise guarantee covers the use of ab20192 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 17 kDa.
RIA Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.

Target

  • Relevance

    The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. BF7 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
  • Database links

    • Alternative names

      • E6 antibody
      • Human papillomavirus type 18 E6 antibody
      • Protein E6 antibody

    References

    This product has been referenced in:

    • Yin S  et al. MicroRNA-130a regulated by HPV18 E6 promotes proliferation and invasion of cervical cancer cells by targeting TIMP2. Exp Ther Med 17:2837-2846 (2019). Read more (PubMed: 30906471) »
    • Cheng Y  et al. Human papillomavirus E6-regulated microRNA-20b promotes invasion in cervical cancer by targeting tissue inhibitor of metalloproteinase 2. Mol Med Rep 16:5464-5470 (2017). Read more (PubMed: 28849054) »
    See all 3 Publications for this product

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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