Overview

  • Product name

  • Description

    Rabbit polyclonal to HRG
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human HRG (internal sequence). NP_000403
    Database link: P04196

  • Positive control

    • Human breast cancer and ovarian cancer tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab198920 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.

Target

  • Relevance

    HRG (histidine-rich glycoprotein) contains two cystatin-like domains and is located in plasma and platelets. The physiological function is not yet known. It binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin, and the lysine-binding site of plasminogen. A potential prothrombotic effect of HRG is indicated by the inhibition of fibrinolysis and the reduction of inhibition of coagulation. Mutations in HRG lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.
  • Cellular localization

    Secreted
  • Database links

  • Alternative names

    • DKFZp779H1622 antibody
    • Histidine proline rich glycoprotein antibody
    • Histidine rich glycoprotein antibody
    • HPRG antibody
    • HRGP antibody
    • Thrombophilia due to elevated HRG antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue labeling HRG using ab198920 at 1/50 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue labeling HRG using ab198920 at 1/50 dilution.

References

ab198920 has not yet been referenced specifically in any publications.

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