Key features and details
- Rabbit polyclonal to HRH3/H3R - Cytoplasmic domain
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-HRH3/H3R antibody - Cytoplasmic domain
See all HRH3/H3R primary antibodies
DescriptionRabbit polyclonal to HRH3/H3R - Cytoplasmic domain
SpecificityBLAST analysis of the peptide immunogen showed no homology with other Human proteins.
Tested applicationsSuitable for: IHC-Pmore details
Unsuitable for: WB
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Horse, Guinea pig, Hamster, Cow, Dog, Monkey, Gorilla, Bat
Synthetic peptide corresponding to Human HRH3/H3R. 16 amino acid peptide from 2nd cytoplasmic domain. NP_009163.2.
Database link: Q9Y5N1
- Human brain (neurons and glia) tissue.
Previously labelled as HRH3.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab188972 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 7 - 15 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
FunctionThe H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization.
Tissue specificityExpressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Cellular localizationCell membrane.
- Information by UniProt
- G protein coupled receptor 97 antibody
- G-protein coupled receptor 97 antibody
- GPCR 97 antibody
ab188972 has not yet been referenced specifically in any publications.