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Signal Transduction Cytoskeleton / ECM Cytoskeleton Microfilaments Actin etc Catenins
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RecombinantRabMAb

Recombinant HRP Anti-delta 1 Catenin/CAS antibody [YE372] (ab202914)

  • Datasheet
  • SDS
  • Certificate of Compliance
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Western blot - HRP Anti-delta 1 Catenin/CAS antibody [YE372] (ab202914)
  • HRP Anti-delta 1 Catenin/CAS antibody [YE372] (ab202914)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • HRP Rabbit monoclonal [YE372] to delta 1 Catenin/CAS
  • Suitable for: WB
  • Reacts with: Human
  • Conjugation: HRP

Overview

  • Product name

    HRP Anti-delta 1 Catenin/CAS antibody [YE372]
    See all delta 1 Catenin/CAS primary antibodies
  • Description

    HRP Rabbit monoclonal [YE372] to delta 1 Catenin/CAS
  • Host species

    Rabbit
  • Conjugation

    HRP
  • Tested Applications & Species

    Application Species
    WB
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide within Human delta 1 Catenin/CAS (N terminal). The exact sequence is proprietary. Before aa101 of Human delta 1 Catenin (isoform 1ABC, 968AA).
    Database link: O60716

  • Positive control

    • WB: HeLa whole cell lysate.
  • General notes

     

     

     

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark.
  • Storage buffer

    pH: 7.40
    Preservative: 0.1% 10% Proclin 300 Solution
    Constituents: 30% Glycerol (glycerin, glycerine), 1% BSA, PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Monoclonal
  • Clone number

    YE372
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Cytoskeleton / ECM
    • Cytoskeleton
    • Microfilaments
    • Actin etc
    • Catenins
    • Stem Cells
    • Signaling Pathways
    • Wnt
    • Cytoplasmic

Associated products

  • Alternative Versions

    • Alexa Fluor® 488 Anti-delta 1 Catenin/CAS antibody [YE372] (ab202913)
    • Alexa Fluor® 647 Anti-delta 1 Catenin/CAS antibody [YE372] (ab203148)
    • Anti-delta 1 Catenin/CAS antibody [YE372] - BSA and Azide free (ab247228)
    • Anti-delta 1 Catenin/CAS antibody [YE372] (ab32095)
  • Isotype control

    • HRP Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab199507)
  • Positive Controls

    • HeLa nuclear extract lysate (ab14655)
  • Related Products

    • ECL Substrate Kit (High Sensitivity) (ab133406)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab202914 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
WB
Human
Application Abreviews Notes
WB
1/5000. Detects a band of approximately 120 kDa (predicted molecular weight: 108 kDa).
Notes
WB
1/5000. Detects a band of approximately 120 kDa (predicted molecular weight: 108 kDa).

Target

  • Function

    Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
  • Tissue specificity

    Expressed in vascular endothelium.
  • Sequence similarities

    Belongs to the beta-catenin family.
    Contains 10 ARM repeats.
  • Domain

    A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
  • Post-translational
    modifications

    Phosphorylated by protein-tyrosine kinases. Dephosphorylated by PTPRJ.
  • Cellular localization

    Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.
  • Target information above from: UniProt accession O60716 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 1500 Human
    • Omim: 601045 Human
    • SwissProt: O60716 Human
    • Unigene: 166011 Human
    • Alternative names

      • Cadherin associated Src substrate antibody
      • Cadherin-associated Src substrate antibody
      • CAS antibody
      • Catenin (cadherin associated protein) delta 1 antibody
      • Catenin delta 1 antibody
      • Catenin delta antibody
      • Catenin delta-1 antibody
      • CTND1_HUMAN antibody
      • CTNND 1 antibody
      • CTNND antibody
      • CTNND1 antibody
      • delta 1 Catenin antibody
      • KIAA0384 antibody
      • p120 antibody
      • P120 CAS antibody
      • p120 catenin antibody
      • P120 CTN antibody
      • p120(cas) antibody
      • p120(ctn) antibody
      • P120CAS antibody
      • P120CTN antibody
      see all

    Images

    • Western blot - HRP Anti-delta 1 Catenin/CAS antibody [YE372] (ab202914)
      Western blot - HRP Anti-delta 1 Catenin/CAS antibody [YE372] (ab202914)
      HRP Anti-delta 1 Catenin/CAS antibody [YE372] (ab202914) at 1/5000 dilution + HeLa whole cell lysate (ab150035) at 10 µg

      Developed using the ECL technique.

      Performed under reducing conditions.

      Predicted band size: 108 kDa
      Observed band size: 120 kDa why is the actual band size different from the predicted?


      Exposure time: 1 minute


      This blot was produced using a 4-12% Bis-tris gel under the MOPS buffer system. The gel was run at 200V for 50 minutes before being transferred onto a Nitrocellulose membrane at 30V for 70 minutes. The membrane was then blocked for an hour using 3% milk before being incubated with ab202914 overnight at 4°C. Antibody binding was visualised using ECL development solution ab133406.

    • HRP Anti-delta 1 Catenin/CAS antibody [YE372] (ab202914)
      HRP Anti-delta 1 Catenin/CAS antibody [YE372] (ab202914)

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    Certificate of Compliance

    To download a Certificate of Compliance, please enter your Lot number below:

    References (0)

    Publishing research using ab202914? Please let us know so that we can cite the reference in this datasheet.

    ab202914 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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