HRP Anti-IgM antibody [CH2] (ab79524)

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Key features and details

  • HRP Mouse monoclonal [CH2] to IgM
  • Reacts with: Human
  • Conjugation: HRP
  • Isotype: IgG1

Overview

  • Product name

    HRP Anti-IgM antibody [CH2]
    See all IgM primary antibodies

  • Description

    HRP Mouse monoclonal [CH2] to IgM

  • Host species

    Mouse

  • Conjugation

    HRP

  • Specificity

    This antibody reacts with Fc fragment of human IgM.

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Purified human IgM.

  • General notes

    The purified antibody is conjugated with Horseradish Peroxidase (HRP) of high specific activity and RZ=3.

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Properties

Target

  • Relevance

    IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. The other isotypes are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type. Characterization of plasma cells in inflammatory conditions: Plasma cell typing can be of use for the classification of intestinal inflammatory conditions such as inflammatory bowel disease and allergic conditions. In the latter a specific increase in the number of IgE plasma cells can be demonstrated.

  • Cellular localization

    Isoform 1: Secreted. During differentiation, B lymphocytes switch from expression of membrane bound IgM to secretion of IgM. Isoform 2: Cell membrane; Single pass type I membrane protein.

  • Database links

    • Alternative names

      • AGM1 antibody
      • Constant region of heavy chain of IgM antibody
      • DKFZp686I15196 antibody
      • DKFZp686I15212 antibody
      • FLJ00385 antibody
      • Hepatitis B virus receptor binding protein antibody
      • Ig mu chain C region antibody
      • IGHM antibody
      • IgM heavy chain constant region antibody
      • Immunoglobulin heavy constant mu antibody
      • Immunoglobulin mu chain antibody
      • Imunoglobulin heavy chain antibody
      • Imunoglobulin heavy chain constant region mu antibody
      • Imunoglobulin heavy chain mu constant region antibody
      • MGC104996 antibody
      • MGC52291 antibody
      • MU antibody
      • VH antibody
      see all

    References (0)

    Publishing research using ab79524? Please let us know so that we can cite the reference in this datasheet.

    ab79524 has not yet been referenced specifically in any publications.

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