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Signal Transduction Growth Factors/Hormones Insulin / Insulin-like
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HRP Anti-Insulin + Proinsulin antibody [D3E7] (ab28063)

  • Datasheet
  • SDS
Reviews (1) Submit a question References (3)

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Abpromise

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Find out more.

Key features and details

  • HRP Mouse monoclonal [D3E7] to Insulin + Proinsulin
  • Reacts with: Mouse, Rat, Cow, Human, Pig
  • Conjugation: HRP
  • Isotype: IgG1

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Conjugation
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Blocking
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10X Blocking Buffer (ab126587)

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Overview

  • Product name

    HRP Anti-Insulin + Proinsulin antibody [D3E7]
    See all Insulin + Proinsulin primary antibodies
  • Description

    HRP Mouse monoclonal [D3E7] to Insulin + Proinsulin
  • Host species

    Mouse
  • Conjugation

    HRP
  • Specificity

    Kd for this antibody is 6.3 x 10-8M. This antibody is specific for both insulin and proinsulin
  • Species reactivity

    Reacts with: Mouse, Rat, Cow, Human, Pig
  • Immunogen

    Human insulin.

  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    pH: 7.40
    Preservative: 0.05% Proclin 300
    Constituents: 0.8% Sodium chloride, 0.02% Potassium chloride, 0.18% Dibasic monohydrogen sodium phosphate, 0.024% Monobasic dihydrogen potassium phosphate
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Monoclonal
  • Clone number

    D3E7
  • Isotype

    IgG1
  • Light chain type

    kappa
  • Research areas

    • Signal Transduction
    • Growth Factors/Hormones
    • Insulin / Insulin-like
    • Neuroscience
    • Neurology process
    • Metabolism
    • Cardiovascular
    • Atherosclerosis
    • Diabetes associated
    • Metabolism
    • Types of disease
    • Diabetes
    • Metabolism
    • Types of disease
    • Cancer
    • Metabolism
    • Types of disease
    • Heart disease

Associated products

  • Affibody® Molecule

    • Anti-Insulin Affibody® Molecule (ab31906)
  • Alternative Versions

    • Biotin Anti-Insulin + Proinsulin antibody [D3E7] (ab20756)
    • Anti-Insulin + Proinsulin antibody [D3E7] (ab8305)
  • Related Products

    • TMB ELISA Substrate (Highest Sensitivity) (ab171522)
    • TMB ELISA Substrate (High Sensitivity) (ab171523)
    • TMB ELISA Substrate (Fast Kinetic Rate) (ab171524)
    • TMB ELISA Substrate (Slow Kinetic Rate) (ab171525)
    • TMB ELISA Substrate (Slower Kinetic Rate) (ab171526)
    • TMB ELISA Substrate (Slowest Kinetic Rate) (ab171527)
    • 450 nm Stop Solution for TMB Substrate (ab171529)
    • 650 nm Stop Solution for TMB Substrate (ab171531)
    • Immunoassay Blocking Buffer (ab171534)
    • Immunoassay Blocking (BSA Free) (ab171535)
  • sELISA pair antibody

    • Anti-Insulin + Proinsulin antibody [D6C4] (ab8304)

Target

  • Relevance

    Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Defects in insulin are the cause of familial hyperproinsulinemia.
  • Cellular localization

    Secreted
  • Database links

    • Entrez Gene: 280829 Cow
    • Entrez Gene: 3630 Human
    • Entrez Gene: 16333 Mouse
    • Entrez Gene: 16334 Mouse
    • Entrez Gene: 24505 Rat
    • Omim: 176730 Human
    • SwissProt: P01317 Cow
    • SwissProt: P01308 Human
    • SwissProt: P01315 Pig
    see all
  • Alternative names

    • ILPR antibody
    • ins antibody
    • Insulin antibody
    • IRDN antibody
    • Proinsulin antibody
    • Proinsulin precursor antibody
    see all

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
    • SDS
  • References (3)

    Publishing research using ab28063? Please let us know so that we can cite the reference in this datasheet.

    ab28063 has been referenced in 3 publications.

    • Kim J  et al. 1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol Attenuates Streptozotocin-Induced Pancreatic Beta Cell Damage by Promoting Glucose Transporter 2 Endocytosis. Mol Cell Biol 39:N/A (2019). PubMed: 31481450
    • Kim J  et al. HX-1171 attenuates pancreatic ß-cell apoptosis and hyperglycemia-mediated oxidative stress via Nrf2 activation in streptozotocin-induced diabetic model. Oncotarget 9:24260-24271 (2018). PubMed: 29849938
    • Xiao F  et al. Ex vivo expanded human regulatory T cells delay islet allograft rejection via inhibiting islet-derived monocyte chemoattractant protein-1 production in CD34+ stem cells-reconstituted NOD-scid IL2r?null mice. PLoS One 9:e90387 (2014). IHC-P . PubMed: 24594640

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    ELISA abreview for Anti-Insulin + Proinsulin antibody [D3E7] (HRP)

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    ELISA
    Sample
    Bos taurus Serum (Blood plasma (EDTA))
    Specification
    Blood plasma (EDTA)
    Blocking step
    BSA as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
    Type
    Sandwich (Detection)
    Read More

    Julie Kim

    Verified customer

    Submitted Nov 16 2018

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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