HRP Anti-TSH antibody [7G12] (ab6070)
Key features and details
- HRP Mouse monoclonal [7G12] to TSH
- Reacts with: Human
- Conjugation: HRP
- Isotype: IgG1
Overview
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Product name
HRP Anti-TSH antibody [7G12]
See all TSH primary antibodies -
Description
HRP Mouse monoclonal [7G12] to TSH -
Host species
Mouse -
Conjugation
HRP -
Specificity
This antibody specifically recognizes the whole molecule of TSH. It does not cross-react with human LH, FSH, HCG. -
Species reactivity
Reacts with: Human -
Immunogen
Full length native protein (purified) from human pituitary gland.
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General notes
This antibody (conjugate) is ELISA paired with ab6069 (capture).Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.40
Preservative: 0.05% Proclin 300
Constituents: 0.024% Monobasic dihydrogen potassium phosphate, 0.18% Dibasic monohydrogen sodium phosphate, 0.02% Potassium chloride, 0.8% Sodium chloride -
Concentration information loading...
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Purity
Protein A purified -
Purification notes
Purity is tested by electrophoresis. -
Clonality
Monoclonal -
Clone number
7G12 -
Myeloma
Sp2/0 -
Isotype
IgG1 -
Research areas
Associated products
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ELISA pair antibody
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Applications
Can be paired for ELISA with Mouse monoclonal [11E4] to TSH (ab6069).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Relevance
Thyroid stimulating hormone, also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones. TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity. -
Cellular localization
Secreted -
Database links
- Entrez Gene: 1081 Human
- Entrez Gene: 7252 Human
- Omim: 118850 Human
- Omim: 188540 Human
- SwissProt: P01215 Human
- SwissProt: P01222 Human
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Alternative names
- CG ALPHA antibody
- CGA antibody
- Chorionic gonadotropin alpha polypeptide antibody
see all
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (2)
ab6070 has been referenced in 2 publications.
- Li L et al. MicroRNA-584 Impairs Cellular Proliferation and Sensitizes Osteosarcoma Cells to Cisplatin and Taxanes by Targeting CCN2. Cancer Manag Res 12:2577-2587 (2020). PubMed: 32346311
- Zhou Y et al. Sulfiredoxin-1 exerts anti-apoptotic and neuroprotective effects against oxidative stress-induced injury in rat cortical astrocytes following exposure to oxygen-glucose deprivation and hydrogen peroxide. Int J Mol Med 36:43-52 (2015). WB . PubMed: 25955519