HRP Anti-VDAC1/Porin antibody [N152B/23] (ab186337)
Key features and details
- HRP Mouse monoclonal [N152B/23] to VDAC1/Porin
- Reacts with: Rat
- Conjugation: HRP
- Isotype: IgG2a
Overview
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Product name
HRP Anti-VDAC1/Porin antibody [N152B/23]
See all VDAC1/Porin primary antibodies -
Description
HRP Mouse monoclonal [N152B/23] to VDAC1/Porin -
Host species
Mouse -
Conjugation
HRP -
Species reactivity
Reacts with: Rat
Predicted to work with: Mouse, Rabbit, Cow, Human, Pig
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Immunogen
Recombinant full length protein corresponding to Human VDAC1/Porin aa 1 to the C-terminus.
Database link: P21796 -
Positive control
- Rat brain lysate.
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General notes
The clone number has been updated from S152B-23 to N152B/23, both clone numbers name the same antibody clone.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
N152B/23 -
Isotype
IgG2a -
Research areas
Associated products
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Alternative Versions
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Recombinant Protein
Target
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Function
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. -
Tissue specificity
Heart, liver and skeletal muscle. -
Sequence similarities
Belongs to the eukaryotic mitochondrial porin family. -
Domain
Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity. -
Cellular localization
Mitochondrion outer membrane. Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 282119 Cow
- Entrez Gene: 7416 Human
- Entrez Gene: 22333 Mouse
- Entrez Gene: 397010 Pig
- Entrez Gene: 100008751 Rabbit
- Entrez Gene: 83529 Rat
- Omim: 604492 Human
- SwissProt: P45879 Cow
see all -
Alternative names
- N2441 antibody
- OMP2 antibody
- POR1 antibody
see all
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab186337 has not yet been referenced specifically in any publications.