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HRP Anti-VDAC1/Porin antibody [N152B/23] (ab186337)

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Key features and details

  • HRP Mouse monoclonal [N152B/23] to VDAC1/Porin
  • Reacts with: Rat
  • Conjugation: HRP
  • Isotype: IgG2a

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Primary
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Protein
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Recombinant Human VDAC1/Porin protein (ab132481)

View more associated products

Overview

  • Product name

    HRP Anti-VDAC1/Porin antibody [N152B/23]
    See all VDAC1/Porin primary antibodies
  • Description

    HRP Mouse monoclonal [N152B/23] to VDAC1/Porin
  • Host species

    Mouse
  • Conjugation

    HRP
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Mouse, Rabbit, Cow, Human, Pig
  • Immunogen

    Recombinant full length protein corresponding to Human VDAC1/Porin aa 1 to the C-terminus.
    Database link: P21796

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control

    • Rat brain lysate.
  • General notes

    The clone number has been updated from S152B-23 to N152B/23, both clone numbers name the same antibody clone.

     

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Monoclonal
  • Clone number

    N152B/23
  • Isotype

    IgG2a
  • Research areas

    • Tags & Cell Markers
    • Subcellular Markers
    • Organelles
    • Mitochondria
    • Signal Transduction
    • Metabolism
    • Mitochondrial
    • Signal Transduction
    • Metabolism
    • Plasma Membrane
    • Channels
    • Isotype/Loading Controls
    • Loading Controls
    • VDAC1 - Mitochondrial Preps
    • Cancer
    • Cancer Metabolism
    • Cellular metabolic process
    • Metabolism
    • Pathways and Processes
    • Mitochondrial Metabolism
    • Mitochondrial markers

Associated products

  • Alternative Versions

    • Biotin Anti-VDAC1/Porin antibody [N152B/23] (ab186262)
    • Anti-VDAC1/Porin antibody [N152B/23] (ab186321)
  • Recombinant Protein

    • Recombinant Human VDAC1/Porin protein (ab132481)

Target

  • Function

    Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
  • Tissue specificity

    Heart, liver and skeletal muscle.
  • Sequence similarities

    Belongs to the eukaryotic mitochondrial porin family.
  • Domain

    Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
  • Cellular localization

    Mitochondrion outer membrane. Cell membrane.
  • Target information above from: UniProt accession P21796 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 282119 Cow
    • Entrez Gene: 7416 Human
    • Entrez Gene: 22333 Mouse
    • Entrez Gene: 397010 Pig
    • Entrez Gene: 100008751 Rabbit
    • Entrez Gene: 83529 Rat
    • Omim: 604492 Human
    • SwissProt: P45879 Cow
    • SwissProt: P21796 Human
    • SwissProt: Q60932 Mouse
    • SwissProt: Q9MZ16 Pig
    • SwissProt: Q9TT15 Rabbit
    • SwissProt: Q9Z2L0 Rat
    • Unigene: 519320 Human
    • Unigene: 709506 Human
    • Unigene: 3555 Mouse
    • Unigene: 54594 Rat
    see all
  • Alternative names

    • N2441 antibody
    • OMP2 antibody
    • POR1 antibody
    • hVDAC1 antibody
    • MGC111064 antibody
    • Mitochondrial Porin antibody
    • Outer mitochondrial membrane protein porin 1 antibody
    • Plasmalemmal porin antibody
    • Porin 31HL antibody
    • Porin 31HM antibody
    • VDAC antibody
    • VDAC-1 antibody
    • Vdac1 antibody
    • VDAC1_HUMAN antibody
    • Voltage dependent anion channel 1 antibody
    • Voltage dependent anion selective channel protein 1 antibody
    • Voltage-dependent anion-selective channel protein 1 antibody
    • YNL055C antibody
    • YNL2441C antibody
    see all

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab186337? Please let us know so that we can cite the reference in this datasheet.

ab186337 has not yet been referenced specifically in any publications.

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