Overview

  • Product name

  • Description

    Rabbit polyclonal to HSD11B2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Horse, Human
  • Immunogen

    Synthetic peptide within Human HSD11B2 aa 170-220 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    HNEVVADAELS PVATFRSCME VNFFGALELT KGLLPLLRSS RGRIVTVGSP


    Database link: P80365

  • Positive control

    • Mouse kidney, horse kidney, rat kidney and human placenta tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab203132 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
  • Tissue specificity

    Found in placenta, kidney, pancreas, prostate, ovary, small intestine and colon.
  • Involvement in disease

    Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME) [MIM:218030]. AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.
  • Sequence similarities

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Cellular localization

    Microsome. Endoplasmic reticulum.
  • Information by UniProt
  • Database links

  • Alternative names

    • 11 beta HSD2 antibody
    • 11 beta hydroxysteroid dehydrogenase type 2 antibody
    • 11 DH2 antibody
    • 11-beta-HSD2 antibody
    • 11-beta-hydroxysteroid dehydrogenase type 2 antibody
    • 11-DH2 antibody
    • AME antibody
    • AME1 antibody
    • Corticosteroid 11 beta dehydrogenase isozyme 2 antibody
    • Corticosteroid 11-beta-dehydrogenase isozyme 2 antibody
    • DHI2_HUMAN antibody
    • HSD11B2 antibody
    • HSD11K antibody
    • HSD2 antibody
    • Hydroxysteroid 11 beta dehydrogenase 2 antibody
    • Hydroxysteroid 11 beta dehydrogenase isoenzyme 2 antibody
    • NAD dependent 11 beta hydroxysteroid dehydrogenase antibody
    • NAD-dependent 11-beta-hydroxysteroid dehydrogenase antibody
    • SDR9C3 antibody
    • Short chain dehydrogenase/reductase family 9C, member 3 antibody
    see all

Images

  • Anti-HSD11B2 antibody (ab203132) at 1/1000 dilution + Mouse kidney lysates

    Secondary
    Conjugated secondary antibody at 1/20000 dilution
  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human placenta tissue labeling HSD11B2 with ab203132 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat kidney tissue labeling HSD11B2 with ab203132 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat kidney tissue labeling HSD11B2 with ab203132 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded horse kidney tissue labeling HSD11B2 with ab203132 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded horse kidney tissue labeling HSD11B2 with ab203132 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse kidney tissue labeling HSD11B2 with ab203132 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

References

ab203132 has not yet been referenced specifically in any publications.

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