Anti-Hsp60 antibody (ab46798)

Rabbit polyclonal Hsp60 antibody. Validated in WB, IP, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Hamster, Human, Pig. Cited in 57 publication(s). Independently reviewed in 10 review(s).

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ab46798 has been referenced in 59 publications.

  • Yen JH  et al. Activation of dynamin-related protein 1 - dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone. J Exp Clin Cancer Res 38:42 (2019). PubMed: 30691497
  • Killackey SA  et al. The mitochondrial Nod-like receptor NLRX1 modifies apoptosis through SARM1. Mol Cell Biochem 453:187-196 (2019). PubMed: 30191480
  • Yang M  et al. Proteomic investigation of the effects of preimplantation factor on human embryo implantation. Mol Med Rep 17:3481-3488 (2018). PubMed: 29286136
  • Li Z  et al. Genipin inhibits the growth of human bladder cancer cells via inactivation of PI3K/Akt signaling. Oncol Lett 15:2619-2624 (2018). PubMed: 29434982
  • Swaroop S  et al. HSP60 critically regulates endogenous IL-1ß production in activated microglia by stimulating NLRP3 inflammasome pathway. J Neuroinflammation 15:177 (2018). WB . PubMed: 29885667
  • Touat M  et al. DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade. J Clin Invest 128:1671-1687 (2018). PubMed: 29447131
  • Wang L  et al. Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles. Cell Metab 28:400-414.e8 (2018). PubMed: 30017354
  • Göttlich C  et al. A combined tissue-engineered/in silico signature tool patient stratification in lung cancer. Mol Oncol 12:1264-1285 (2018). PubMed: 29797762
  • Boutoual R  et al. Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPAR?-UCP2-AMPK axis. Sci Rep 8:1163 (2018). PubMed: 29348686
  • Hensen F  et al. The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair. Sci Rep 8:5368 (2018). PubMed: 29599527
  • Hauser DN  et al. Hexokinases link DJ-1 to the PINK1/parkin pathway. Mol Neurodegener 12:70 (2017). WB . PubMed: 28962651
  • Janczar S  et al. WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response. Cell Death Dis 8:e2955 (2017). WB . PubMed: 28749468
  • Tang C  et al. Aspartate ß-hydroxylase disrupts mitochondrial DNA stability and function in hepatocellular carcinoma. Oncogenesis 6:e362 (2017). PubMed: 28714949
  • Steen KA  et al. FABP4/aP2 Regulates Macrophage Redox Signaling and Inflammasome Activation via Control of UCP2. Mol Cell Biol 37:N/A (2017). WB ; Mouse . PubMed: 27795298
  • Hu M  et al. Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy. Mol Cell 66:141-153.e6 (2017). PubMed: 28388439
  • Kassas N  et al. Comparative Characterization of Phosphatidic Acid Sensors and Their Localization during Frustrated Phagocytosis. J Biol Chem 292:4266-4279 (2017). PubMed: 28115519
  • Vasaturo M  et al. A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPAR? partial agonist with anti-proliferative ability. Sci Rep 7:41273 (2017). Human . PubMed: 28117438
  • Radomski N  et al. Mito-xenophagic killing of bacteria is coordinated by a metabolic switch in dendritic cells. Sci Rep 7:3923 (2017). PubMed: 28634388
  • Gao J  et al. Icariside II, a novel phosphodiesterase 5 inhibitor, protects against H2 O2 -induced PC12 cells death by inhibiting mitochondria-mediated autophagy. J Cell Mol Med 21:375-386 (2017). PubMed: 27642051
  • Rosselin M  et al. L-OPA1 regulates mitoflash biogenesis independently from membrane fusion. EMBO Rep 18:451-463 (2017). PubMed: 28174208
  • Chung HK  et al. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol 216:149-165 (2017). WB . PubMed: 27986797
  • Casciati A  et al. Age-related effects of X-ray irradiation on mouse hippocampus. Oncotarget 7:28040-58 (2016). WB . PubMed: 27057631
  • Lumbera WM  et al. Heat Shock Protein Augmentation of Angelica gigas Nakai Root Hot Water Extract on Adipogenic Differentiation in Murine 3T3-L1 Preadipocytes. Asian-Australas J Anim Sci 29:419-27 (2016). WB . PubMed: 26950875
  • Duanmu Y  et al. Comparative proteomic analysis of the effects of high-concentrate diet on the hepatic metabolism and inflammatory response in lactating dairy goats. J Anim Sci Biotechnol 7:5 (2016). WB . PubMed: 26855776
  • Itakura E  et al. Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation. Mol Cell 63:21-33 (2016). WB ; Human . PubMed: 27345149
  • Sommeregger W  et al. Proteomic differences in recombinant CHO cells producing two similar antibody fragments. Biotechnol Bioeng 113:1902-12 (2016). WB . PubMed: 26913574
  • Testoni B  et al. Ribavirin restores IFNa responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes. Gut 65:672-82 (2016). Human . PubMed: 26082258
  • Lv B  et al. Activated Microglia Induce Bone Marrow Mesenchymal Stem Cells to Produce Glial Cell-Derived Neurotrophic Factor and Protect Neurons Against Oxygen-Glucose Deprivation Injury. Front Cell Neurosci 10:283 (2016). PubMed: 28018176
  • Hiller S  et al. Alpha-lipoic acid supplementation protects enzymes from damage by nitrosative and oxidative stress. Biochim Biophys Acta 1860:36-45 (2016). PubMed: 26344063
  • Singh H  et al. MaxiK channel interactome reveals its interaction with GABA transporter 3 and heat shock protein 60 in the mammalian brain. Neuroscience 317:76-107 (2016). PubMed: 26772433
  • Dai W  et al. By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice. Oncotarget 6:13703-17 (2015). WB ; Human . PubMed: 25938543
  • Huebbers CU  et al. High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma. Oncotarget 6:36172-84 (2015). PubMed: 26452026
  • Song M  et al. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab 21:273-85 (2015). PubMed: 25600785
  • Kao TY  et al. Mitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex. Cell Death Dis 6:e1642 (2015). PubMed: 25675302
  • Wan D  et al. Integrated Transcriptional and Proteomic Analysis of Growth Hormone Suppression Mediated by Trichothecene T-2 Toxin in Rat GH3 Cells. Toxicol Sci 147:326-38 (2015). PubMed: 26141394
  • Bannwarth S  et al. A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement. Brain 137:2329-45 (2014). PubMed: 24934289
  • Suenaga S  et al. Active hexose-correlated compound down-regulates HSP27 of pancreatic cancer cells, and helps the cytotoxic effect of gemcitabine. Anticancer Res 34:141-6 (2014). Human . PubMed: 24403454
  • Hauser DN  et al. Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain. PLoS One 9:e94646 (2014). WB ; Mouse . PubMed: 24722488
  • Xia M  et al. Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling. J Virol 88:5152-64 (2014). PubMed: 24574393
  • Soares F  et al. The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis. J Biol Chem 289:19317-30 (2014). Mouse . PubMed: 24867956
  • Beilstein F  et al. Proteomic analysis of lipid droplets from Caco-2/TC7 enterocytes identifies novel modulators of lipid secretion. PLoS One 8:e53017 (2013). WB . PubMed: 23301014
  • Slotta-Huspenina J  et al. A specific expression profile of heat-shock proteins and glucose-regulated proteins is associated with response to neoadjuvant chemotherapy in oesophageal adenocarcinomas. Br J Cancer 109:370-8 (2013). PubMed: 23839491
  • Yentrapalli R  et al. The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation. PLoS One 8:e70024 (2013). PubMed: 23936371
  • Martinez-Outschoorn UE  et al. Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells. Cell Cycle 11:3956-63 (2012). PubMed: 23082721
  • Slotta-Huspenina J  et al. Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomas. PLoS One 7:e41420 (2012). WB, IHC ; Human . PubMed: 22911792
  • Martinez-Outschoorn UE  et al. Ketone body utilization drives tumor growth and metastasis. Cell Cycle 11:3964-71 (2012). PubMed: 23082722
  • Gilbert JS  et al. Placental and vascular adaptations to exercise training before and during pregnancy in the rat. Am J Physiol Regul Integr Comp Physiol 303:R520-6 (2012). WB ; Rat . PubMed: 22814667
  • He J  et al. Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis. Nucleic Acids Res : (2012). WB ; Human . PubMed: 22453275
  • Elachouri G  et al. OPA1 links human mitochondrial genome maintenance to mtDNA replication and distribution. Genome Res 21:12-20 (2011). WB ; Human . PubMed: 20974897
  • Reyes A  et al. Actin and myosin contribute to mammalian mitochondrial DNA maintenance. Nucleic Acids Res 39:5098-108 (2011). WB ; Human . PubMed: 21398640
  • Sircoulomb F  et al. ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. EMBO Mol Med 3:153-66 (2011). WB, ICC/IF ; Human . PubMed: 21328542
  • Devi L & Ohno M Mitochondrial dysfunction and accumulation of the ß-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice. Neurobiol Dis : (2011). WB ; Mouse . PubMed: 21933711
  • O'Dwyer D  et al. The proteomics of colorectal cancer: identification of a protein signature associated with prognosis. PLoS One 6:e27718 (2011). IHC-Fr ; Human . PubMed: 22125622
  • Meleady P  et al. Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype. BMC Biotechnol 11:78 (2011). WB . PubMed: 21781345
  • Singh SB  et al. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol 12:1154-65 (2010). WB, ICC/IF ; Human . PubMed: 21102437
  • Puga Yung GL  et al. Heat shock protein-derived T-cell epitopes contribute to autoimmune inflammation in pediatric Crohn's disease. PLoS One 4:e7714 (2009). IHC-P ; Human . PubMed: 19888320
  • Hernlund E  et al. Ovarian carcinoma cells with low levels of beta-F1-ATPase are sensitive to combined platinum and 2-deoxy-D-glucose treatment. Mol Cancer Ther 8:1916-23 (2009). WB ; Human . PubMed: 19567816
  • Baron B  et al. Isolation of a growth factor stress-induced pancreatic cancer sub-population: insight into changes due to micro-environment. Cancer Genomics Proteomics 12:49-55 (0). PubMed: 25770187
  • Baron B  et al. Comparative proteomic analysis of two stress-management strategies in pancreatic cancer. Cancer Genomics Proteomics 12:83-7 (0). PubMed: 25770192

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