Anti-Hsp60 antibody (ab46798)

Rabbit polyclonal Hsp60 antibody. Validated in WB, IP, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Hamster, Human, Pig. Cited in 57 publication(s). Independently reviewed in 10 review(s).

Publishing research using ab46798? Please let us know so that we can cite the reference in this datasheet.

ab46798 has been referenced in 59 publications.

  • Yen JH  et al. Activation of dynamin-related protein 1 - dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone. J Exp Clin Cancer Res 38:42 (2019). PubMed: 30691497
  • Killackey SA  et al. The mitochondrial Nod-like receptor NLRX1 modifies apoptosis through SARM1. Mol Cell Biochem 453:187-196 (2019). PubMed: 30191480
  • Yang M  et al. Proteomic investigation of the effects of preimplantation factor on human embryo implantation. Mol Med Rep 17:3481-3488 (2018). PubMed: 29286136
  • Li Z  et al. Genipin inhibits the growth of human bladder cancer cells via inactivation of PI3K/Akt signaling. Oncol Lett 15:2619-2624 (2018). PubMed: 29434982
  • Swaroop S  et al. HSP60 critically regulates endogenous IL-1ß production in activated microglia by stimulating NLRP3 inflammasome pathway. J Neuroinflammation 15:177 (2018). WB . PubMed: 29885667
  • Touat M  et al. DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade. J Clin Invest 128:1671-1687 (2018). PubMed: 29447131
  • Wang L  et al. Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles. Cell Metab 28:400-414.e8 (2018). PubMed: 30017354
  • Göttlich C  et al. A combined tissue-engineered/in silico signature tool patient stratification in lung cancer. Mol Oncol 12:1264-1285 (2018). PubMed: 29797762
  • Boutoual R  et al. Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPAR?-UCP2-AMPK axis. Sci Rep 8:1163 (2018). PubMed: 29348686
  • Hensen F  et al. The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair. Sci Rep 8:5368 (2018). PubMed: 29599527
  • Hauser DN  et al. Hexokinases link DJ-1 to the PINK1/parkin pathway. Mol Neurodegener 12:70 (2017). WB . PubMed: 28962651
  • Janczar S  et al. WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response. Cell Death Dis 8:e2955 (2017). WB . PubMed: 28749468
  • Tang C  et al. Aspartate ß-hydroxylase disrupts mitochondrial DNA stability and function in hepatocellular carcinoma. Oncogenesis 6:e362 (2017). PubMed: 28714949
  • Steen KA  et al. FABP4/aP2 Regulates Macrophage Redox Signaling and Inflammasome Activation via Control of UCP2. Mol Cell Biol 37:N/A (2017). WB ; Mouse . PubMed: 27795298
  • Hu M  et al. Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy. Mol Cell 66:141-153.e6 (2017). PubMed: 28388439
  • Kassas N  et al. Comparative Characterization of Phosphatidic Acid Sensors and Their Localization during Frustrated Phagocytosis. J Biol Chem 292:4266-4279 (2017). PubMed: 28115519
  • Vasaturo M  et al. A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPAR? partial agonist with anti-proliferative ability. Sci Rep 7:41273 (2017). Human . PubMed: 28117438
  • Radomski N  et al. Mito-xenophagic killing of bacteria is coordinated by a metabolic switch in dendritic cells. Sci Rep 7:3923 (2017). PubMed: 28634388
  • Gao J  et al. Icariside II, a novel phosphodiesterase 5 inhibitor, protects against H2 O2 -induced PC12 cells death by inhibiting mitochondria-mediated autophagy. J Cell Mol Med 21:375-386 (2017). PubMed: 27642051
  • Rosselin M  et al. L-OPA1 regulates mitoflash biogenesis independently from membrane fusion. EMBO Rep 18:451-463 (2017). PubMed: 28174208
  • Chung HK  et al. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol 216:149-165 (2017). WB . PubMed: 27986797
  • Casciati A  et al. Age-related effects of X-ray irradiation on mouse hippocampus. Oncotarget 7:28040-58 (2016). WB . PubMed: 27057631
  • Lumbera WM  et al. Heat Shock Protein Augmentation of Angelica gigas Nakai Root Hot Water Extract on Adipogenic Differentiation in Murine 3T3-L1 Preadipocytes. Asian-Australas J Anim Sci 29:419-27 (2016). WB . PubMed: 26950875
  • Duanmu Y  et al. Comparative proteomic analysis of the effects of high-concentrate diet on the hepatic metabolism and inflammatory response in lactating dairy goats. J Anim Sci Biotechnol 7:5 (2016). WB . PubMed: 26855776
  • Itakura E  et al. Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation. Mol Cell 63:21-33 (2016). WB ; Human . PubMed: 27345149
  • Sommeregger W  et al. Proteomic differences in recombinant CHO cells producing two similar antibody fragments. Biotechnol Bioeng 113:1902-12 (2016). WB . PubMed: 26913574
  • Testoni B  et al. Ribavirin restores IFNa responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes. Gut 65:672-82 (2016). Human . PubMed: 26082258
  • Lv B  et al. Activated Microglia Induce Bone Marrow Mesenchymal Stem Cells to Produce Glial Cell-Derived Neurotrophic Factor and Protect Neurons Against Oxygen-Glucose Deprivation Injury. Front Cell Neurosci 10:283 (2016). PubMed: 28018176
  • Hiller S  et al. Alpha-lipoic acid supplementation protects enzymes from damage by nitrosative and oxidative stress. Biochim Biophys Acta 1860:36-45 (2016). PubMed: 26344063
  • Singh H  et al. MaxiK channel interactome reveals its interaction with GABA transporter 3 and heat shock protein 60 in the mammalian brain. Neuroscience 317:76-107 (2016). PubMed: 26772433
  • Dai W  et al. By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice. Oncotarget 6:13703-17 (2015). WB ; Human . PubMed: 25938543
  • Huebbers CU  et al. High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma. Oncotarget 6:36172-84 (2015). PubMed: 26452026
  • Song M  et al. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab 21:273-85 (2015). PubMed: 25600785
  • Kao TY  et al. Mitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex. Cell Death Dis 6:e1642 (2015). PubMed: 25675302
  • Wan D  et al. Integrated Transcriptional and Proteomic Analysis of Growth Hormone Suppression Mediated by Trichothecene T-2 Toxin in Rat GH3 Cells. Toxicol Sci 147:326-38 (2015). PubMed: 26141394
  • Bannwarth S  et al. A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement. Brain 137:2329-45 (2014). PubMed: 24934289
  • Suenaga S  et al. Active hexose-correlated compound down-regulates HSP27 of pancreatic cancer cells, and helps the cytotoxic effect of gemcitabine. Anticancer Res 34:141-6 (2014). Human . PubMed: 24403454
  • Hauser DN  et al. Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain. PLoS One 9:e94646 (2014). WB ; Mouse . PubMed: 24722488
  • Xia M  et al. Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling. J Virol 88:5152-64 (2014). PubMed: 24574393
  • Soares F  et al. The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis. J Biol Chem 289:19317-30 (2014). Mouse . PubMed: 24867956
  • Beilstein F  et al. Proteomic analysis of lipid droplets from Caco-2/TC7 enterocytes identifies novel modulators of lipid secretion. PLoS One 8:e53017 (2013). WB . PubMed: 23301014
  • Slotta-Huspenina J  et al. A specific expression profile of heat-shock proteins and glucose-regulated proteins is associated with response to neoadjuvant chemotherapy in oesophageal adenocarcinomas. Br J Cancer 109:370-8 (2013). PubMed: 23839491
  • Yentrapalli R  et al. The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation. PLoS One 8:e70024 (2013). PubMed: 23936371
  • Martinez-Outschoorn UE  et al. Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells. Cell Cycle 11:3956-63 (2012). PubMed: 23082721
  • Slotta-Huspenina J  et al. Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomas. PLoS One 7:e41420 (2012). WB, IHC ; Human . PubMed: 22911792
  • Martinez-Outschoorn UE  et al. Ketone body utilization drives tumor growth and metastasis. Cell Cycle 11:3964-71 (2012). PubMed: 23082722
  • Gilbert JS  et al. Placental and vascular adaptations to exercise training before and during pregnancy in the rat. Am J Physiol Regul Integr Comp Physiol 303:R520-6 (2012). WB ; Rat . PubMed: 22814667
  • He J  et al. Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis. Nucleic Acids Res : (2012). WB ; Human . PubMed: 22453275
  • Elachouri G  et al. OPA1 links human mitochondrial genome maintenance to mtDNA replication and distribution. Genome Res 21:12-20 (2011). WB ; Human . PubMed: 20974897
  • Reyes A  et al. Actin and myosin contribute to mammalian mitochondrial DNA maintenance. Nucleic Acids Res 39:5098-108 (2011). WB ; Human . PubMed: 21398640
  • Sircoulomb F  et al. ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. EMBO Mol Med 3:153-66 (2011). WB, ICC/IF ; Human . PubMed: 21328542
  • Devi L & Ohno M Mitochondrial dysfunction and accumulation of the ß-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice. Neurobiol Dis : (2011). WB ; Mouse . PubMed: 21933711
  • O'Dwyer D  et al. The proteomics of colorectal cancer: identification of a protein signature associated with prognosis. PLoS One 6:e27718 (2011). IHC-Fr ; Human . PubMed: 22125622
  • Meleady P  et al. Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype. BMC Biotechnol 11:78 (2011). WB . PubMed: 21781345
  • Singh SB  et al. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol 12:1154-65 (2010). WB, ICC/IF ; Human . PubMed: 21102437
  • Puga Yung GL  et al. Heat shock protein-derived T-cell epitopes contribute to autoimmune inflammation in pediatric Crohn's disease. PLoS One 4:e7714 (2009). IHC-P ; Human . PubMed: 19888320
  • Hernlund E  et al. Ovarian carcinoma cells with low levels of beta-F1-ATPase are sensitive to combined platinum and 2-deoxy-D-glucose treatment. Mol Cancer Ther 8:1916-23 (2009). WB ; Human . PubMed: 19567816
  • Baron B  et al. Isolation of a growth factor stress-induced pancreatic cancer sub-population: insight into changes due to micro-environment. Cancer Genomics Proteomics 12:49-55 (0). PubMed: 25770187
  • Baron B  et al. Comparative proteomic analysis of two stress-management strategies in pancreatic cancer. Cancer Genomics Proteomics 12:83-7 (0). PubMed: 25770192

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