Anti-Hsp90 antibody [AC88] (ab13492)

Mouse monoclonal Hsp90 antibody [AC88]. Validated in WB, IP, IHC, ICC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Sheep, Rabbit, Chicken, Guinea pig, Hamster, Cow, Dog, Human, Pig and more.

Publishing research using ab13492? Please let us know so that we can cite the reference in this datasheet.

ab13492 has been referenced in 47 publications.

  • Dong L  et al. HSP90 interacts with HMGCR and promotes the progression of hepatocellular carcinoma. Mol Med Rep 19:524-532 (2019). PubMed: 30483734
  • Eckersley-Maslin M  et al. Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program. Genes Dev 33:194-208 (2019). PubMed: 30692203
  • Nabi F  et al. Clinical efficiency and safety of Hsp90 inhibitor Novobiocin in avian tibial dyschondroplasia. J Vet Pharmacol Ther N/A:N/A (2018). PubMed: 30004119
  • Dunne M  et al. Hyperthermia-mediated drug delivery induces biological effects at the tumor and molecular levels that improve cisplatin efficacy in triple negative breast cancer. J Control Release 282:35-45 (2018). PubMed: 29673642
  • Wang F  et al. Blocking nuclear export of HSPA8 after heat shock stress severely alters cell survival. Sci Rep 8:16820 (2018). PubMed: 30429537
  • Lv C  et al. The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG. Cell Death Dis 9:165 (2018). PubMed: 29416003
  • Jeong GR  et al. Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration. Mol Neurodegener 13:8 (2018). PubMed: 29439717
  • Lv JW  et al. Inhibition of microRNA-214 promotes epithelial-mesenchymal transition process and induces interstitial cystitis in postmenopausal women by upregulating Mfn2. Exp Mol Med 49:e357 (2017). WB . PubMed: 28729638
  • Nagaraj R  et al. Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation. Cell 168:210-223.e11 (2017). PubMed: 28086092
  • San Gil R  et al. Using bicistronic constructs to evaluate the chaperone activities of heat shock proteins in cells. Sci Rep 7:2387 (2017). PubMed: 28539657
  • Judge LM  et al. A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress. JCI Insight 2:N/A (2017). PubMed: 28724793
  • Xu Q  et al. HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma. Mol Cancer 16:178 (2017). PubMed: 29262861
  • Devasthanam AS & Tomasi TB Dicer protein levels elevated by mild hyperthermia promote a pro-survival phenotype. Oncotarget 8:67001-67016 (2017). Human . PubMed: 28978012
  • Wu M  et al. Isolation of exosomes from whole blood by integrating acoustics and microfluidics. Proc Natl Acad Sci U S A 114:10584-10589 (2017). PubMed: 28923936
  • Ulbrich F  et al. The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ß1 in rats' retinal ganglion cells after ischemia and reperfusion injury. J Neuroinflammation 14:130 (2017). IHC-P ; Rat . PubMed: 28655348
  • Yang X  et al. The histological characteristics, age-related thickness change of skin, and expression of the HSPs in the skin during hair cycle in yak (Bos grunniens). PLoS One 12:e0176451 (2017). WB, IHC ; Other species . PubMed: 28463974
  • Ji QQ  et al. Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain. Nucleic Acids Res 45:7367-7381 (2017). WB . PubMed: 28575390
  • Li Z  et al. HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients. Cell Rep 19:2515-2528 (2017). WB ; Human . PubMed: 28636940
  • Liu X  et al. HSP90 inhibits apoptosis and promotes growth by regulating HIF-1a abundance in hepatocellular carcinoma. Int J Mol Med 37:825-35 (2016). PubMed: 26846697
  • Pinet S  et al. TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells. Oncotarget 7:50349-50364 (2016). PubMed: 27385098
  • Nokin MJ  et al. Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis. Elife 5:N/A (2016). IP ; Human . PubMed: 27759563
  • Tang HB  et al. Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4. Sci Rep 6:30529 (2016). WB ; Mouse . PubMed: 27456665
  • Hodge G  et al. Steroid resistance in COPD is associated with impaired molecular chaperone Hsp90 expression by pro-inflammatory lymphocytes. Respir Res 17:135 (2016). PubMed: 27769261
  • Qian C  et al. Precise Characterization of the Penumbra Revealed by MRI: A Modified Photothrombotic Stroke Model Study. PLoS One 11:e0153756 (2016). IHC-P ; Mouse . PubMed: 27093556
  • Cao ZW  et al. HSP90 expression and its association with wighteone metabolite response in HER2-positive breast cancer cells. Oncol Lett 11:3719-3722 (2016). PubMed: 27313682
  • Traylen C  et al. Identification of Epstein-Barr Virus Replication Proteins in Burkitt's Lymphoma Cells. Pathogens 4:739-51 (2015). WB . PubMed: 26529022
  • Zhu J  et al. Effects of the novel heat shock protein 90 inhibitor AUY922 in renal cell carcinoma ACHN and 786-O cells. Oncol Lett 10:941-945 (2015). WB ; Human . PubMed: 26622600
  • Cheng W  et al. Role of the novel HSP90 inhibitor AUY922 in hepatocellular carcinoma: Potential for therapy. Mol Med Rep 12:2451-6 (2015). WB . PubMed: 25955495
  • Mukherjee P  et al. SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons. J Immunol 195:4913-21 (2015). ICC/IF . PubMed: 26423149
  • Ulbrich F  et al. Neuroprotective effects of Argon are mediated via an ERK-1/2 dependent regulation of heme-oxygenase-1 in retinal ganglion cells. J Neurochem 134:717-27 (2015). PubMed: 25876941
  • Petrosyan A & Cheng PW Golgi fragmentation induced by heat shock or inhibition of heat shock proteins is mediated by non-muscle myosin IIA via its interaction with glycosyltransferases. Cell Stress Chaperones 19:241-54 (2014). WB, ICC/IF ; Human . PubMed: 23990450
  • Fang Q  et al. HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase ß. Nat Commun 5:5513 (2014). PubMed: 25423885
  • Donet M  et al. Elastin peptides regulate HT-1080 fibrosarcoma cell migration and invasion through an Hsp90-dependent mechanism. Br J Cancer 111:139-148 (2014). PubMed: 24874477
  • Kobayashi Y  et al. Summer heat stress affects prostaglandin synthesis in the bovine oviduct. Reproduction 146:103-10 (2013). WB ; Cow . PubMed: 23704311
  • French JB  et al. Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome. Proc Natl Acad Sci U S A 110:2528-33 (2013). WB ; Human . PubMed: 23359685
  • Ozdemir AY  et al. PINCH in the cellular stress response to tau-hyperphosphorylation. PLoS One 8:e58232 (2013). WB ; Human . PubMed: 23554879
  • Egger ME  et al. Inhibition of autophagy with chloroquine is effective in melanoma. J Surg Res 184:274-81 (2013). PubMed: 23706562
  • Muschol-Steinmetz C  et al. Function of survivin in trophoblastic cells of the placenta. PLoS One 8:e73337 (2013). PubMed: 24069188
  • Maffei S  et al. Beneficial effect of directional freezing on in vitro viability of cryopreserved sheep whole ovaries and ovarian cortical slices. Hum Reprod N/A:N/A (2013). IHC-Fr ; Sheep . PubMed: 24135077
  • Yang C  et al. Histone deacetylase inhibitors increase glucocerebrosidase activity in Gaucher disease by modulation of molecular chaperones. Proc Natl Acad Sci U S A 110:966-71 (2013). IP . PubMed: 23277556
  • Velázquez MM  et al. Changes in the expression of Heat Shock Proteins in ovaries from bovines with cystic ovarian disease induced by ACTH. Res Vet Sci 95:1059-67 (2013). IHC-P . PubMed: 23937990
  • Hoel AW  et al. Mitochondrial heat shock protein-90 modulates vascular smooth muscle cell survival and the vascular injury response in vivo. Am J Pathol 181:1151-7 (2012). IHC-Fr ; Mouse . PubMed: 22841823
  • Bernadskaya YY  et al. UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph polarize F-actin during embryonic morphogenesis by regulating the WAVE/SCAR actin nucleation complex. PLoS Genet 8:e1002863 (2012). WB . PubMed: 22876199
  • Pennarossa G  et al. Characterization of the constitutive pig ovary heat shock chaperone machinery and its response to acute thermal stress or to seasonal variations. Biol Reprod 87:119 (2012). WB, IHC-P ; Pig . PubMed: 23018186
  • Wu Y  et al. Developmental expression of heat shock proteins 60, 70, 90, and A2 in rabbit testis. Cell Tissue Res 344:355-63 (2011). IHC-P ; Rabbit . PubMed: 21538228
  • Peng Y  et al. The 90-kDa Heat Shock Protein Stabilizes the Polysomal Ribonuclease 1 mRNA Endonuclease to Degradation by the 26S Proteasome. Mol Biol Cell 19:546-52 (2008). WB ; African green monkey . PubMed: 18045990
  • Cohen AA  et al. Dynamic proteomics of individual cancer cells in response to a drug. Science 322:1511-6 (2008). WB ; Human . PubMed: 19023046

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up