Anti-HSV1 + HSV2 gD antibody [2C10] (ab6507)
Key features and details
- Mouse monoclonal [2C10] to HSV1 + HSV2 gD
- Suitable for: WB, ELISA, ICC/IF
- Reacts with: Herpes simplex virus, Human herpesvirus 2
- Isotype: IgG2a
Overview
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Product name
Anti-HSV1 + HSV2 gD antibody [2C10] -
Description
Mouse monoclonal [2C10] to HSV1 + HSV2 gD -
Host species
Mouse -
Tested applications
Suitable for: WB, ELISA, ICC/IFmore details -
Species reactivity
Reacts with: Herpes simplex virus, Human herpesvirus 2 -
Immunogen
Tissue, cells or virus corresponding to HSV1 + HSV2 gD.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
2C10 -
Myeloma
NS1/1-Ag4-1 -
Isotype
IgG2a -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab6507 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/10000.
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ELISA |
1/102400.
|
|
ICC/IF |
1/3200 - 1/25600.
1/3,200 (HSV-2) - 1/25,600 (HSV-1). |
Notes |
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WB
1/10000. |
ELISA
1/102400. |
ICC/IF
1/3200 - 1/25600. 1/3,200 (HSV-2) - 1/25,600 (HSV-1). |
Target
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Relevance
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) are two species of the herpes virus family, Herpesviridae, which cause infections in humans. They are also called Human Herpes Virus 1 and 2 (HHV-1 and HHV-2) and are neurotropic and neuroinvasive viruses; they enter and hide in the human nervous system, accounting for their durability in the human body. Under a microscope, HSV- 1 and 2 are virtually identical, sharing approximately 50% of their DNA. Both types infect the body's mucosal surfaces, usually the mouth or genitals, and then establish latency in the nervous system. HSV-1 is commonly associated with herpes outbreaks of the face known as cold sores or fever blisters, whereas HSV-2 is more often associated with genital herpes. Herpes simplex viruses (HSV) use multiple and sequential receptors to enter host cells. HSV glycoprotein D (gD) has been implicated in binding to cellular receptors that facilitate virus penetration into cells. Herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) is an essential component of the entry apparatus that is responsible for viral penetration and subsequent cell-cell spread. -
Database links
- Entrez Gene: 1487358 Herpes simplex virus
- Entrez Gene: 2703406 Herpes simplex virus
- SwissProt: Q69091 Herpes simplex virus
- SwissProt: Q69467 Herpes simplex virus
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Alternative names
- Envelope glycoprotein D antibody
- GD antibody
- Glycoprotein D antibody
- US6 antibody
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (23)
ab6507 has been referenced in 23 publications.
- Barnes J et al. An ESCRT/VPS4 Envelopment Trap To Examine the Mechanism of Alphaherpesvirus Assembly and Transport in Neurons. J Virol 96:e0217821 (2022). PubMed: 35045266
- Wang Z et al. Oleanolic Acid Derivative AXX-18 Exerts Antiviral Activity by Inhibiting the Expression of HSV-1 Viral Genes UL8 and UL52. Viruses 14:N/A (2022). PubMed: 35746758
- Sanchez AD et al. Receptor Interactome Discovery with RDIMIS, a Membrane Protein Interaction Screen Using Recombinant Extracellular Vesicles. Curr Protoc 2:e483 (2022). PubMed: 35822836
- Jones LM et al. Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[n]urils. ACS Infect Dis 8:2084-2095 (2022). PubMed: 36062478
- Koujah L et al. Entry receptor bias in evolutionarily distant HSV-1 clinical strains drives divergent ocular and nervous system pathologies. Ocul Surf 21:238-249 (2021). PubMed: 33766740