Overview

  • Product name

  • Description

    Rabbit polyclonal to HSV2 ICP4
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ELISAmore details
  • Species reactivity

    Reacts with: Recombinant fragment
    Predicted to work with: Other species
  • Immunogen

    A synthetic peptide corresponding to N terminal residues of Human HSV2 ICP4

Properties

Applications

Our Abpromise guarantee covers the use of ab96431 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 135 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA 1/2000 - 1/5000.

Target

  • Relevance

    ICP4 (Trans-acting transcriptional protein ICP4) is a transcriptional transactivator that binds with high affinity to the sequence 5'-ATCGTC-3'. ICP4 may interact with and recruit specific components of the general transcription machinery to viral promoters and stabilize their formation for transcription initiation. ICP4 negatively regulates its own transcription. This immediate early (EI) protein may be necessary in virion for viral pathogenesis. ICP4 is a homodimer and interacts with transcriptional regulator ICP27; this interaction is required for proper incorporation of ICP4 into virions. The long stretch of Ser is a major site of phosphorylation. Only the phosphorylated forms are capable of interacting with beta or gamma genes. ICP4 belongs to the herpesviridae ICP4/IE140/IE180 family.
  • Alternative names

    • Alpha 4 protein antibody
    • Alpha4 protein antibody
    • ICP4 antibody
    • IE175 antibody
    • Infected cell protein 4 antibody
    • RS1 antibody
    • Trans acting transcriptional protein ICP4 antibody
    • Transcriptional activator IE175 antibody
    • Transcriptional regulator ICP4 antibody
    see all

References

This product has been referenced in:

  • Zhang M  et al. Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4+ T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4. Front Immunol 9:2932 (2018). Read more (PubMed: 30619292) »
  • Stanley JA  et al. A fetal whole ovarian culture model for the evaluation of CrVI-induced developmental toxicity during germ cell nest breakdown. Toxicol Appl Pharmacol 289:58-69 (2015). Read more (PubMed: 26348139) »
See all 2 Publications for this product

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